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Mouse Anti-ACD Recombinant Antibody (V2-179249) (CBMAB-A0521-YC)

Provided herein is a Mouse monoclonal antibody against Human ACD, Shelterin Complex Subunit And Telomerase Recruitment Factor. The antibody can be used for immunoassay techniques, such as IHC-P, WB.
See all ACD antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179249
Antibody Isotype
IgG1
Application
IHC-P, WB

Basic Information

Immunogen
Full length human recombinant protein of human ACD(NP_001075955) produced in HEK293T cell.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:2,000
IHC1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.3, 1% BSA, 50% Glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
adrenocortical dysplasia homolog (mouse)
Introduction
ACD is a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other comp
Entrez Gene ID
65057
UniProt ID
Q96AP0
Alternative Names
ACD, Shelterin Complex Subunit And Telomerase Recruitment Factor; POT1 And TIN2-Interacting Protein; TIN2 Interacting Protein 1; TINT1; PIP1; PTOP;
Function
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
Biological Process
Depurination
Establishment of protein localization to telomere
Intracellular protein transport
Negative regulation of DNA recombination at telomere
Negative regulation of telomere maintenance via telomerase
Positive regulation of histone exchange
Positive regulation of single-stranded telomeric DNA binding
Positive regulation of telomerase activity
Positive regulation of telomere maintenance via telomerase
Protection from non-homologous end joining at telomere
Protein localization to chromosome, telomeric region
Telomere assembly
Telomere capping
Telomere maintenance
Telomere maintenance via semi-conservative replication
Telomere maintenance via telomerase
Cellular Location
Nucleus; Telomere
Involvement in disease
A form of dyskeratosis congenita, a rare multisystem disorder caused by defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy.
A form of dyskeratosis congenita, a rare multisystem disorder caused by defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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