Mouse Anti-ARFIP2 Recombinant Antibody (2B5) (CBMAB-A0454-LY)

Name: Mouse Anti-ARFIP2 Recombinant Antibody (2B5)
SKU: CBMAB-A0454-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2B5

Application

WB, ELISA

Immunogen

ARFIP2 (AAH00392, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

ADP-ribosylation factor interacting protein 2

Entrez Gene ID

23647

UniProt ID

P53365

Alternative Names

POR1

Function

Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2 (PubMed:26507660).
Participates also in autophagy by regulating the starvation-depdendent trafficking of ATG9A vesicles which deliver the PI4-kinase to the autophagosome initiation site (PubMed:31204568).
In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG (PubMed:26296658).

Biological Process

Actin cytoskeleton organization Source: UniProtKB
Autophagy Source: UniProtKB-KW
Intracellular protein transport Source: GO_Central
Lamellipodium assembly Source: UniProtKB
Regulation of Arp2/3 complex-mediated actin nucleation Source: GO_Central
Ruffle organization Source: UniProtKB
Small GTPase mediated signal transduction Source: ProtInc

Cellular Location

Golgi apparatus; Trans-Golgi network membrane

Qin, K., Tian, G., Zhou, D., & Chen, G. (2021). Circular RNA circ-ARFIP2 regulates proliferation, migration and invasion in human vascular smooth muscle cells via miR-338-3p-dependent modulation of KDR. Metabolic Brain Disease, 1-12.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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