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Mouse Anti-ARFIP2 Recombinant Antibody (2B5) (CBMAB-A0454-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2B5
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
ARFIP2 (AAH00392, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ADP-ribosylation factor interacting protein 2
Entrez Gene ID
23647
UniProt ID
P53365
Alternative Names
POR1
Function
Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2 (PubMed:26507660).
Participates also in autophagy by regulating the starvation-depdendent trafficking of ATG9A vesicles which deliver the PI4-kinase to the autophagosome initiation site (PubMed:31204568).
In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG (PubMed:26296658).
Biological Process
Actin cytoskeleton organization Source: UniProtKB
Autophagy Source: UniProtKB-KW
Intracellular protein transport Source: GO_Central
Lamellipodium assembly Source: UniProtKB
Regulation of Arp2/3 complex-mediated actin nucleation Source: GO_Central
Ruffle organization Source: UniProtKB
Small GTPase mediated signal transduction Source: ProtInc
Cellular Location
Golgi apparatus; Trans-Golgi network membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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