ARFIP2

The protein is putative target protein of ADP-ribosylation factor and involved in membrane ruffling.

Full Name

ADP-ribosylation factor interacting protein 2

Function

Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2 (PubMed:26507660).
Participates also in autophagy by regulating the starvation-depdendent trafficking of ATG9A vesicles which deliver the PI4-kinase to the autophagosome initiation site (PubMed:31204568).
In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG (PubMed:26296658).

Biological Process

Actin cytoskeleton organization Source: UniProtKB
Autophagy Source: UniProtKB-KW
Intracellular protein transport Source: GO_Central
Lamellipodium assembly Source: UniProtKB
Regulation of Arp2/3 complex-mediated actin nucleation Source: GO_Central
Ruffle organization Source: UniProtKB
Small GTPase mediated signal transduction Source: ProtInc

Cellular Location

Golgi apparatus; Trans-Golgi network membrane