Rabbit Anti-ATG10 Recombinant Antibody (SR1389) (CBMAB-1157-CN)

Name: Rabbit Anti-ATG10 Recombinant Antibody (SR1389)
SKU: CBMAB-1157-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

SR1389

Application

WB, IP

Immunogen

A synthesized peptide derived from human ATG10.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:500-1:2,000
IP	1:50

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 150mM NaCl, 50% glycerol

Preservative

0.02% sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Autophagy Related 10

Introduction

Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. This protein acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. It likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). This protein plays a role in adenovirus-mediated cell lysis.

Entrez Gene ID

83734

UniProt ID

Q9H0Y0

Alternative Names

APG10; APG10L; pp12616

Function

E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity).
Plays a role in adenovirus-mediated cell lysis.

Biological Process

Autophagy Source: UniProtKB
ER overload response Source: BHF-UCL
Macroautophagy Source: GO_Central
Positive regulation of protein modification process Source: UniProtKB
Protein lipidation Source: UniProtKB
Protein modification by small protein conjugation Source: UniProtKB
Protein transport Source: UniProtKB-KW

Cellular Location

Cytoplasm

Abbasi Teshnizi, F., Kazemipour, N., Nazifi, S., Bagheri Lankarani, K., Sepehrimanesh, M., & Razeghian Jahromi, I. (2021). A study on the potential role of autophagy‐related protein 10 as a biomarker for ulcerative colitis. Physiological Reports, 9(7), e14825.

Shen, H., Lin, Z., Shi, H., Wu, L., Ma, B., Li, H., ... & Yin, X. (2020). MiR-221/222 promote migration and invasion, and inhibit autophagy and apoptosis by modulating ATG10 in aggressive papillary thyroid carcinoma. 3 Biotech, 10(8), 1-11.

Han, Z., Wang, W., Lv, X., Zong, Y., Liu, S., Liu, Z., ... & Song, L. (2019). ATG10 (autophagy-related 10) regulates the formation of autophagosome in the anti-virus immune response of pacific oyster (Crassostrea gigas). Fish & shellfish immunology, 91, 325-332.

Catanese, A., Olde Heuvel, F., Mulaw, M., Demestre, M., Higelin, J., Barbi, G., ... & Boeckers, T. M. (2019). Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulation. Autophagy, 15(10), 1719-1737.

Zhang, M. Q., Li, J. R., Peng, Z. G., & Zhang, J. P. (2018). Differential effects of autophagy-related 10 protein on HCV replication and autophagy flux are mediated by its cysteine44 and cysteine135. Frontiers in immunology, 9, 2176.

Nooraei, M. S., Noori-Zadeh, A., Darabi, S., Rajaei, F., Golmohammadi, Z., & Abbaszadeh, H. A. (2018). Low level of autophagy-related gene 10 (ATG10) expression in the 6-hydroxydopamine rat model of Parkinson’s disease. Iranian biomedical journal, 22(1), 15.

Zhao, Q., Hu, Z. Y., Zhang, J. P., Jiang, J. D., Ma, Y. Y., Li, J. R., ... & Chen, J. H. (2017). Dual roles of two isoforms of autophagy-related gene ATG10 in HCV-subgenomic replicon mediated autophagy flux and innate immunity. Scientific reports, 7(1), 1-15.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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