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Mouse Anti-B2M Recombinant Antibody (CBYY-0049) (CBMAB-0049-YY)

This product is mouse antibody that recognizes B2M. The antibody CBYY-0049 can be used for immunoassay techniques such as: ELISA, FC, IHC, WB
See all B2M antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBYY-0049
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Soluble neonatal Fc receptor (FcRn).
Specificity
Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.0
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Beta-2-Microglobulin
Introduction
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercataBovinelic hypoproteinemia.
B2M (Beta-2-Microglobulin) is a Protein Coding gene.
Diseases associated with B2M include Immunodeficiency 43 and Amyloidosis, Familial Visceral.
Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System.
Gene Ontology (GO) annotations related to this gene include identical protein binding.
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).
Entrez Gene ID
UniProt ID
Alternative Names
Beta-2-Microglobulin; Beta Chain Of MHC Class I Molecules; Beta-2-Microglobin; IMD43;
Function
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).
Biological Process
Amyloid fibril formation Source: ARUK-UCL
Antibacterial humoral response Source: UniProtKB
Antigen processing and presentation of endogenous peptide antigen via MHC class I Source: BHF-UCL
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
Antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent Source: Ensembl
Antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cellular response to iron(III) ion Source: Ensembl
Cellular response to iron ion Source: BHF-UCL
Cellular response to lipopolysaccharide Source: UniProtKB
Cellular response to nicotine Source: ARUK-UCL
Defense response to Gram-negative bacterium Source: UniProtKB
Defense response to Gram-positive bacterium Source: UniProtKB
Innate immune response Source: UniProtKB
Interferon-gamma-mediated signaling pathway Source: Reactome
Iron ion homeostasis Source: BHF-UCL
Iron ion transport Source: Ensembl
Learning or memory Source: ARUK-UCL
Modulation by symbiont of host defense response Source: Reactome
Modulation of age-related behavioral decline Source: ARUK-UCL
Negative regulation of epithelial cell proliferation Source: ARUK-UCL
Negative regulation of forebrain neuron differentiation Source: ARUK-UCL
Negative regulation of neurogenesis Source: ARUK-UCL
Negative regulation of neuron projection development Source: Ensembl
Negative regulation of receptor binding Source: BHF-UCL
Neutrophil degranulation Source: Reactome
Positive regulation of cellular senescence Source: ARUK-UCL
Positive regulation of ferrous iron binding Source: BHF-UCL
Positive regulation of protein binding Source: BHF-UCL
Positive regulation of receptor binding Source: BHF-UCL
Positive regulation of receptor-mediated endocytosis Source: BHF-UCL
Positive regulation of T cell cytokine production Source: BHF-UCL
Positive regulation of T cell mediated cytotoxicity Source: Ensembl
Positive regulation of transferrin receptor binding Source: BHF-UCL
Protein homotetramerization Source: ARUK-UCL
Protein refolding Source: Ensembl
Regulation of defense response to virus by virus Source: Reactome
Regulation of erythrocyte differentiation Source: Ensembl
Regulation of immune response Source: Reactome
Regulation of iron ion transport Source: BHF-UCL
Regulation of membrane depolarization Source: UniProtKB
Response to cadmium ion Source: Ensembl
Response to drug Source: Ensembl
Response to molecule of bacterial origin Source: Ensembl
Retina homeostasis Source: UniProtKB
T cell differentiation in thymus Source: Ensembl
Cellular Location
Secreted; Cell surface. Detected in serum and urine (PubMed:1336137, PubMed:7554280). (Microbial infection) In the presence of M.tuberculosis EsxA-EsxB complex decreased amounts of B2M are found on the cell surface (PubMed:25356553).
Involvement in disease
Immunodeficiency 43 (IMD43): A disorder characterized by marked reduction in serum concentrations of immunoglobulins and albumin, and hypoproteinemia due to hypercatabolism. Patients may suffer from recurrent respiratory tract infections and severe skin disease.
Amyloidosis 8 (AMYL8): The disease is caused by variants affecting the gene represented in this entry. Apart from the presence of causative mutations, beta-2-microglobulin may adopt the fibrillar configuration of amyloid when its serum levels are persistently high. High beta(2)-microglobulin serum levels result in amyloidosis in patients on long-term hemodialysis (PubMed:7918443). In contrast to patients with dialysis-related amyloidosis, patients with hereditary amyloidosis have normal circulating concentrations of beta2-microglobulin (PubMed:22693999). A form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system.
PTM
Glycation of Ile-21 is observed in long-term hemodialysis patients.

Shi, F., Sun, L., & Kaptoge, S. (2021). Association of beta-2-microglobulin and cardiovascular events and mortality: A systematic review and meta-analysis. Atherosclerosis.

Germano, G., Lu, S., Rospo, G., Lamba, S., Rousseau, B., Fanelli, S., ... & Bardelli, A. (2021). CD4 T cell dependent rejection of beta 2 microglobulin null mismatch repair deficient tumors. Cancer Discovery.

Tang, F., Zhao, Y. H., Zhang, Q., Wei, W., Tian, S. F., Li, C., ... & Li, Z. Q. (2021). Impact of beta‐2 microglobulin expression on the survival of glioma patients via modulating the tumor immune microenvironment. CNS Neuroscience & Therapeutics.

Liang, S., Li, Q., Lai, Q., Zhou, Y., Zhang, H., Chen, X., ... & Yang, X. (2021). Beta-2-Microglobulin is an Independent Risk Factor for Asymptomatic Carotid Atherosclerosis in Patients with Primary Aldosteronism. Journal of Atherosclerosis and Thrombosis, 62851.

Bento, L., Díaz‐López, A., Barranco, G., Martín‐Moreno, A. M., Baile, M., Martín, A., ... & Grupo Español de Linfomas y Trasplante Autólogo (GELTAMO). (2020). New prognosis score including absolute lymphocyte/monocyte ratio, red blood cell distribution width and beta‐2 microglobulin in patients with diffuse large B‐cell lymphoma treated with R‐CHOP: Spanish Lymphoma Group Experience (GELTAMO). British journal of haematology, 188(6), 888-897.

Snahnicanova, Z., Kasubova, I., Kalman, M., Grendar, M., Mikolajcik, P., Gabonova, E., ... & Lasabova, Z. (2020). Genetic and epigenetic analysis of the beta-2-microglobulin gene in microsatellite instable colorectal cancer. Clinical and experimental medicine, 20(1), 87-95.

Barrow, P., Richman, S. D., Wallace, A. J., Handley, K., Hutchins, G. G., Kerr, D., ... & Hill, J. (2019). Confirmation that somatic mutations of beta‐2 microglobulin correlate with a lack of recurrence in a subset of stage II mismatch repair deficient colorectal cancers from the QUASAR trial. Histopathology, 75(2), 236-246.

Zhang, C., Li, F., Long, T., Li, F., Peng, L., Xia, K., ... & Yang, T. (2019). Beta 2-microglobulin and the severity of coronary stenosis in patients with acute coronary syndrome. Heart, Lung and Circulation, 28(4), 575-582.

Clendenning, M., Huang, A., Jayasekara, H., Lorans, M., Preston, S., O’Callaghan, N., ... & Buchanan, D. D. (2018). Somatic mutations of the coding microsatellites within the beta-2-microglobulin gene in mismatch repair-deficient colorectal cancers and adenomas. Familial cancer, 17(1), 91-100.

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For research use only. Not intended for any clinical use.

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