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Mouse Anti-BTG1 Recombinant Antibody (CBYY-0864) (CBMAB-0867-YY)

This product is mouse antibody that recognizes BTG1. The antibody CBYY-0864 can be used for immunoassay techniques such as: IHC
See all BTG1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-0864
Antibody Isotype
IgG1
Application
WB, IP

Basic Information

Immunogen
Recombinant protein corresponding to the C-terminal region of BTG1 of human origin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BTG Anti-Proliferation Factor 1
Introduction
This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia.
Entrez Gene ID
694
UniProt ID
P62324
Alternative Names
BTG Anti-Proliferation Factor 1; B-Cell Translocation Gene 1, Anti-Proliferative; B-Cell Translocation Gene 1 Protein; Protein BTG1; APRO2;
Function
Anti-proliferative protein.
Biological Process
Cell migration Source: UniProtKB
Negative regulation of cell growth Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of mitotic cell cycle Source: GO_Central
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of endothelial cell differentiation Source: UniProtKB
Positive regulation of fibroblast apoptotic process Source: UniProtKB
Positive regulation of myoblast differentiation Source: MGI
Regulation of transcription, DNA-templated Source: UniProtKB
Cellular Location
Nucleoplasm; Nucleus; Cytoplasm
Involvement in disease
A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with MYC.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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