Mouse Anti-BTG1 Recombinant Antibody (CBYY-1952) (CBMAB-2301-YY)

Name: Mouse Anti-BTG1 Recombinant Antibody (CBYY-1952)
SKU: CBMAB-2301-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-1952

Application

Immunogen

Full length human recombinant protein of human BTG1 produced in E.coli.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
IHC	1:150

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

BTG Anti-Proliferation Factor 1

Introduction

This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia.

Entrez Gene ID

694

UniProt ID

P62324

Alternative Names

BTG Anti-Proliferation Factor 1; B-Cell Translocation Gene 1, Anti-Proliferative; B-Cell Translocation Gene 1 Protein; Protein BTG1; APRO2;

Function

Anti-proliferative protein.

Biological Process

Cell migration Source: UniProtKB
Negative regulation of cell growth Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of mitotic cell cycle Source: GO_Central
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of endothelial cell differentiation Source: UniProtKB
Positive regulation of fibroblast apoptotic process Source: UniProtKB
Positive regulation of myoblast differentiation Source: MGI
Regulation of transcription, DNA-templated Source: UniProtKB

Cellular Location

Nucleoplasm; Nucleus; Cytoplasm

Involvement in disease

A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with MYC.

Li, Y., Huo, J., He, J., Zhang, Y., & Ma, X. (2020). BTG1 inhibits malignancy as a novel prognosis signature in endometrial carcinoma. Cancer cell international, 20(1), 1-14.

Li, E., Han, K., & Zhou, X. (2019). microRNA-27a-3p down-regulation inhibits malignant biological behaviors of ovarian cancer by targeting BTG1. Open Medicine, 14(1), 577-585.

Zhu, J., & Han, S. (2019). Lidocaine inhibits cervical cancer cell proliferation and induces cell apoptosis by modulating the lncRNA-MEG3/miR-421/BTG1 pathway. American journal of translational research, 11(9), 5404.

Huang, S. M. (2019). Mechanism of Translation Regulation of BTG1 by eIF3 (Doctoral dissertation, Brandeis University).

Zhao, X., Chen, G. Q., & Cao, G. M. (2019). Abnormal expression and mechanism of miR-330-3p/BTG1 axis in hepatocellular carcinoma. Eur Rev Med Pharmacol Sci, 23(16), 6888-98.

He, C., Yu, T., Shi, Y., Ma, C., Yang, W., Fang, L., ... & Liu, Z. (2017). MicroRNA 301A promotes intestinal inflammation and colitis-associated cancer development by inhibiting BTG1. Gastroenterology, 152(6), 1434-1448.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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