BTG1

This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia.

Full Name

BTG Anti-Proliferation Factor 1

Function

Anti-proliferative protein.

Biological Process

Cell migration Source: UniProtKB
Negative regulation of cell growth Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of mitotic cell cycle Source: GO_Central
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of endothelial cell differentiation Source: UniProtKB
Positive regulation of fibroblast apoptotic process Source: UniProtKB
Positive regulation of myoblast differentiation Source: MGI
Regulation of transcription, DNA-templated Source: UniProtKB

Cellular Location

Nucleoplasm; Nucleus; Cytoplasm

Involvement in disease

A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with MYC.