Mouse Anti-BTN1A1 Recombinant Antibody (CBYY-0905) (CBMAB-0908-YY)

Name: Mouse Anti-BTN1A1 Recombinant Antibody (CBYY-0905)
SKU: CBMAB-0908-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-0905

Application

WB, E, FC

Immunogen

Purified recombinant fragment of human BTN1A1 (aa: extra 27-242) expressed in E. coli.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2b

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:10,000
WB	1:500-1:2,000
FC	1:200-1:400

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

0.05% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Butyrophilin Subfamily 1 Member A1

Introduction

Butyrophilin is the major protein associated with fat droplets in the milk. It is a member of the immunoglobulin superfamily. It may have a cell surface receptor function. The human butyrophilin gene is localized in the major histocompatibility complex (MHC) class I region of 6p and may have arisen relatively recently in evolution by the shuffling of exons between 2 ancestral gene families

Entrez Gene ID

Human	696
Cattle	282157

UniProt ID

Human	Q13410
Cattle	P18892

Alternative Names

Butyrophilin Subfamily 1 Member A1; BTN; BT; BK14H9.2 (Butyrophilin, Subfamily 1, Member A1); Butyrophilin, Subfamily 1, Member A1; BTN1;

Function

May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity).
Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity).

Biological Process

Adaptive immune response Source: Reactome
Regulation of cytokine production Source: GO_Central
T cell receptor signaling pathway Source: GO_Central

Cellular Location

Secreted; Membrane

Topology

Extracellular: 27-242 aa
Helical: 243-269 aa
Cytoplasmic: 270-526 aa

PTM

N-glycosylated.

Rigau, M., Uldrich, A. P., & Behren, A. (2021). Targeting butyrophilins for cancer immunotherapy. Trends in immunology.

Han, L., Zhang, M., Xing, Z., Coleman, D. N., Liang, Y., Loor, J. J., & Yang, G. (2020). Knockout of butyrophilin subfamily 1 member A1 (BTN1A1) alters lipid droplet formation and phospholipid composition in bovine mammary epithelial cells. Journal of Animal Science and Biotechnology, 11(1), 1-11.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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