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Mouse Anti-CHGB Recombinant Antibody (CBYY-C0723) (CBMAB-C2142-YY)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
CBYY-C0723
Application
WB, IP
Immunogen
Amino acids 200-389 of Chr-B of rat.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Chromogranin B
Entrez Gene ID
1114
UniProt ID
P05060
Alternative Names
Activated Leukocyte Cell Adhesion Molecule; CD166 Antigen; MEMD; Activated Leucocyte Cell Adhesion Molecule; CD166;
Function
Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
Biological Process
Cellular protein metabolic process Source: Reactome
Post-translational protein modification Source: Reactome
Cellular Location
Secreted. Neuroendocrine and endocrine secretory granules.
PTM
Extensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in different tissues (By similarity).
O-glycosylated.

Herold, Z., Herold, M., Rosta, K., Doleschall, M., & Somogyi, A. (2020). Lower serum chromogranin B level is associated with type 1 diabetes and with type 2 diabetes patients with intensive conservative insulin treatment. Diabetology & Metabolic Syndrome, 12(1), 1-5.

Bearrows, S. C., Bauchle, C. J., Becker, M., Haldeman, J. M., Swaminathan, S., & Stephens, S. B. (2019). Chromogranin B regulates early-stage insulin granule trafficking from the Golgi in pancreatic islet β-cells. Journal of cell science, 132(13), jcs231373.

Stenman, A., Svahn, F., Hojjat-Farsangi, M., Zedenius, J., Söderkvist, P., Gimm, O., ... & Juhlin, C. C. (2019). Molecular profiling of pheochromocytoma and abdominal paraganglioma stratified by the PASS algorithm reveals chromogranin B as associated with histologic prediction of malignant behavior. The American journal of surgical pathology, 43(3), 409-421.

Yadav, G. P., Wang, H., Ouwendijk, J., Annamalai, M., Cross, S., Wang, Q., ... & Jiang, Q. X. (2019). Membrane insertion of chromogranin B for granule maturation in regulated secretion. bioRxiv.

Yadav, G. P., Zheng, H., Yang, Q., Douma, L. G., Bloom, L. B., & Jiang, Q. X. (2018). Secretory granule protein chromogranin B (CHGB) forms an anion channel in membranes. Life science alliance, 1(5).

Yadav, G. P., Zheng, H., Yang, Q., Douma, L. G., Annamalai, M., Bloom, L. B., ... & Jiang, Q. X. (2018). Novel organelle anion channels formed by chromogranin B drive normal granule maturation in endocrine cells. bioRxiv, 302828.

Shin, J. G., Kim, J. H., Park, C. S., Kim, B. J., Kim, J. W., Choi, I. G., ... & Woo, S. I. (2017). Gender-specific associations between CHGB genetic variants and schizophrenia in a Korean population. Yonsei medical journal, 58(3), 619-625.

Ohta, Y., Soucy, G. S., Phaneuf, D., Audet, J. N., Gros-Louis, F., Yamashita, T., ... & Abe, K. (2017). The role of variant chromogranin b as disease modifier in japanese female amyotrophic lateral sclerosis. Journal of the Neurological Sciences, 381, 101.

Yadav, G. P., Yang, Q., & Jiang, Q. X. (2017). Chromogranin B Serves the Long-Sought-After Anion Conductance in Regulated Secretion. Biophysical Journal, 112(3), 184a.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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