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Rabbit Anti-CHGB Recombinant Antibody (BA0374) (CBMAB-0238CQ)

This product is a rabbit antibody that recognizes CHGB. The antibody BA0374 can be used for immunoassay techniques such as: WB.
See all CHGB antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
BA0374
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Chromogranin B
Introduction
This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. Craig et al. (1986) assigned the chromogranin B gene to chromosome 20. Craig et al. (1987) showed by in situ hybridization that the CHGB locus is on 20pter-p12. Jenkins et al. (1991) mapped the murine gene, symbolized Scg-1, to chromosome 2 by in situ hybridization and by interspecific backcross analysis.
Entrez Gene ID
1114
UniProt ID
P05060
Alternative Names
Chromogranin B; Secretogranin B; Secretogranin I; Chromogranin-B; SCG1; CGB; SgI; Secretogranin 1
Function
Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
Biological Process
Cellular protein metabolic process Source: Reactome
Post-translational protein modification Source: Reactome
Cellular Location
Secreted. Neuroendocrine and endocrine secretory granules.
PTM
Extensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in different tissues (By similarity).
O-glycosylated.

Herold, Z., Herold, M., Rosta, K., Doleschall, M., & Somogyi, A. (2020). Lower serum chromogranin B level is associated with type 1 diabetes and with type 2 diabetes patients with intensive conservative insulin treatment. Diabetology & Metabolic Syndrome, 12(1), 1-5.

Bearrows, S. C., Bauchle, C. J., Becker, M., Haldeman, J. M., Swaminathan, S., & Stephens, S. B. (2019). Chromogranin B regulates early-stage insulin granule trafficking from the Golgi in pancreatic islet β-cells. Journal of cell science, 132(13), jcs231373.

Stenman, A., Svahn, F., Hojjat-Farsangi, M., Zedenius, J., Söderkvist, P., Gimm, O., ... & Juhlin, C. C. (2019). Molecular profiling of pheochromocytoma and abdominal paraganglioma stratified by the PASS algorithm reveals chromogranin B as associated with histologic prediction of malignant behavior. The American journal of surgical pathology, 43(3), 409-421.

Yadav, G. P., Wang, H., Ouwendijk, J., Annamalai, M., Cross, S., Wang, Q., ... & Jiang, Q. X. (2019). Membrane insertion of chromogranin B for granule maturation in regulated secretion. bioRxiv.

Yadav, G. P., Zheng, H., Yang, Q., Douma, L. G., Bloom, L. B., & Jiang, Q. X. (2018). Secretory granule protein chromogranin B (CHGB) forms an anion channel in membranes. Life science alliance, 1(5).

Yadav, G. P., Zheng, H., Yang, Q., Douma, L. G., Annamalai, M., Bloom, L. B., ... & Jiang, Q. X. (2018). Novel organelle anion channels formed by chromogranin B drive normal granule maturation in endocrine cells. bioRxiv, 302828.

Shin, J. G., Kim, J. H., Park, C. S., Kim, B. J., Kim, J. W., Choi, I. G., ... & Woo, S. I. (2017). Gender-specific associations between CHGB genetic variants and schizophrenia in a Korean population. Yonsei medical journal, 58(3), 619-625.

Ohta, Y., Soucy, G. S., Phaneuf, D., Audet, J. N., Gros-Louis, F., Yamashita, T., ... & Abe, K. (2017). The role of variant chromogranin b as disease modifier in japanese female amyotrophic lateral sclerosis. Journal of the Neurological Sciences, 381, 101.

Yadav, G. P., Yang, Q., & Jiang, Q. X. (2017). Chromogranin B Serves the Long-Sought-After Anion Conductance in Regulated Secretion. Biophysical Journal, 112(3), 184a.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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