Mouse Anti-DYRK4 Recombinant Antibody (3B9) (CBMAB-D2032-YC)

Name: Mouse Anti-DYRK4 Recombinant Antibody (3B9)
SKU: CBMAB-D2032-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3B9

Application

ELISA, WB

Immunogen

DYRK4 (AAH31244, 421 a.a. ~ 520 a.a) partial recombinant protein with GST tag. The immunogen sequence: FFPSETRKDK VQGCHHSSRK ADEITKETTE KTKDSPTKHV QHSGDQQDCL QHGADTVQLP QLVDAPKKSE AAVGAEVSMT SPGQSKNFSL KNTNVLPPIV

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 421-520

More Infomation

Target

Full Name

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4

Introduction

DYRK4 is an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Entrez Gene ID

8798

UniProt ID

Q9NR20

Alternative Names

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 4; EC 2.7.12.1; Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 4; Dual Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 4; EC 2.7.12;

Research Area

Possible non-essential role in spermiogenesis.

Biological Process

Peptidyl-serine phosphorylation Source: GO_Central
Peptidyl-threonine phosphorylation Source: GO_Central

Cellular Location

Isoform 1: Cytoplasm
Isoform 2: Cytoplasm; Nucleus.

PTM

Autophosphorylation on Tyr-264 in the activation loop is required for kinase activity.

Liu, C. C., Veeraraghavan, J., Tan, Y., Kim, J. A., Wang, X., Loo, S. K., ... & Wang, X. S. (2021). A Novel Neoplastic Fusion Transcript, RAD51AP1-DYRK4, Confers Sensitivity to the MEK Inhibitor Trametinib in Aggressive Breast CancersNeoplastic RAD51AP1-DYRK4 Fusion Transcript in Breast Cancer. Clinical Cancer Research, 27(3), 785-798.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-DYRK4 Recombinant Antibody (CBT2898) (CAT#: V2LY-0625-LY1892)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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