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Rabbit Anti-LPAR3 Recombinant Antibody (EG1029) (CBMAB-EN1213-LY)

The product is antibody recognizes EDG7. The antibody EG1029 immunoassay techniques such as: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:40000.
See all LPAR3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1029
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from C-terminal of human EDG7.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
lysophosphatidic acid receptor 3
Introduction
This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.
Entrez Gene ID
23566
UniProt ID
Q9UBY5
Alternative Names
EDG7; GPCR; LPA3; Edg-7; LP-A3; HOFNH30; RP4-678I3
Function
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Bleb assemblyIEA:Ensembl
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Gene expressionIEA:Ensembl
Positive regulation of collateral sproutingIEA:Ensembl
Positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of MAPK cascadeIEA:Ensembl
Regulation of metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-31
Helical: 32-52
Cytoplasmic: 53-67
Helical: 68-88
Extracellular: 89-101
Helical: 102-124
Cytoplasmic: 125-146
Helical: 147-167
Extracellular: 168-186
Helical: 187-207
Cytoplasmic: 208-240
Helical: 241-261
Extracellular: 262-276
Helical: 277-297
Cytoplasmic: 298-353

Doutt, S. W., Longo, J. F., & Carroll, S. L. (2023). LPAR1 and aberrantly expressed LPAR3 differentially promote the migration and proliferation of malignant peripheral nerve sheath tumor cells. Glia, 71(3), 742-757.

Hwang, S. H., Kim, H. G., & Lee, M. (2022). Paradoxical downregulation of LPAR3 exerts tumor-promoting activity through autophagy induction in Ras-transformed cells. BMC cancer, 22(1), 1-15.

Liu, X., Yin, Z., Wu, Y., Zhan, Q., Huang, H., & Fan, J. (2022). Circular RNA lysophosphatidic acid receptor 3 (circ-LPAR3) enhances the cisplatin resistance of ovarian cancer. Bioengineered, 13(2), 3739-3750.

Lin, Y. N., Audira, G., Malhotra, N., Ngoc Anh, N. T., Siregar, P., Lu, J. H., ... & Hsiao, C. D. (2020). A novel function of the lysophosphatidic acid receptor 3 (LPAR3) gene in Zebrafish on modulating anxiety, circadian rhythm locomotor activity, and short-term memory. International journal of molecular sciences, 21(8), 2837.

Xia, W., & Jie, W. (2020). ZEB1-AS1/miR-133a-3p/LPAR3/EGFR axis promotes the progression of thyroid cancer by regulating PI3K/AKT/mTOR pathway. Cancer Cell International, 20, 1-13.

Shi, Y., Fang, N., Li, Y., Guo, Z., Jiang, W., He, Y., ... & Chen, Y. (2020). Circular RNA LPAR3 sponges microRNA‐198 to facilitate esophageal cancer migration, invasion, and metastasis. Cancer science, 111(8), 2824-2836.

Wei, M., Li, L., Zhang, Y., Zhang, M., & Su, Z. (2020). Downregulated circular RNA zRANB1 mediates Wnt5a/β-Catenin signaling to promote neuropathic pain via miR-24-3p/LPAR3 axis in CCI rat models. Gene, 761, 145038.

Byrnes, C. C., Jia, W., Alshamrani, A. A., Kuppa, S. S., & Murph, M. M. (2019). miR-122-5p expression and secretion in melanoma cells is amplified by the LPAR3 SH3–binding domain to regulate Wnt1. Molecular Cancer Research, 17(1), 299-309.

Hua, X., Chen, J., & Wu, L. (2019). Identification of candidate biomarkers associated with apoptosis in melanosis coli: GNG5, LPAR3, MAPK8, and PSMC6. Bioscience reports, 39(1), BSR20181369.

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For research use only. Not intended for any clinical use.

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