Rabbit Anti-LPAR3 Recombinant Antibody (EG1029) (CBMAB-EN1213-LY)

Name: Rabbit Anti-LPAR3 Recombinant Antibody (EG1029)
SKU: CBMAB-EN1213-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1029

Application

WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:40000

Immunogen

The antibody was produced against synthesized peptide derived from C-terminal of human EDG7.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

lysophosphatidic acid receptor 3

Introduction

This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.

Entrez Gene ID

23566

UniProt ID

Q9UBY5

Alternative Names

EDG7; GPCR; LPA3; Edg-7; LP-A3; HOFNH30; RP4-678I3

Function

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Bleb assemblyIEA:Ensembl
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Gene expressionIEA:Ensembl
Positive regulation of collateral sproutingIEA:Ensembl
Positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of MAPK cascadeIEA:Ensembl
Regulation of metabolic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-31
Helical: 32-52
Cytoplasmic: 53-67
Helical: 68-88
Extracellular: 89-101
Helical: 102-124
Cytoplasmic: 125-146
Helical: 147-167
Extracellular: 168-186
Helical: 187-207
Cytoplasmic: 208-240
Helical: 241-261
Extracellular: 262-276
Helical: 277-297
Cytoplasmic: 298-353

Doutt, S. W., Longo, J. F., & Carroll, S. L. (2023). LPAR1 and aberrantly expressed LPAR3 differentially promote the migration and proliferation of malignant peripheral nerve sheath tumor cells. Glia, 71(3), 742-757.

Hwang, S. H., Kim, H. G., & Lee, M. (2022). Paradoxical downregulation of LPAR3 exerts tumor-promoting activity through autophagy induction in Ras-transformed cells. BMC cancer, 22(1), 1-15.

Liu, X., Yin, Z., Wu, Y., Zhan, Q., Huang, H., & Fan, J. (2022). Circular RNA lysophosphatidic acid receptor 3 (circ-LPAR3) enhances the cisplatin resistance of ovarian cancer. Bioengineered, 13(2), 3739-3750.

Lin, Y. N., Audira, G., Malhotra, N., Ngoc Anh, N. T., Siregar, P., Lu, J. H., ... & Hsiao, C. D. (2020). A novel function of the lysophosphatidic acid receptor 3 (LPAR3) gene in Zebrafish on modulating anxiety, circadian rhythm locomotor activity, and short-term memory. International journal of molecular sciences, 21(8), 2837.

Xia, W., & Jie, W. (2020). ZEB1-AS1/miR-133a-3p/LPAR3/EGFR axis promotes the progression of thyroid cancer by regulating PI3K/AKT/mTOR pathway. Cancer Cell International, 20, 1-13.

Shi, Y., Fang, N., Li, Y., Guo, Z., Jiang, W., He, Y., ... & Chen, Y. (2020). Circular RNA LPAR3 sponges microRNA‐198 to facilitate esophageal cancer migration, invasion, and metastasis. Cancer science, 111(8), 2824-2836.

Wei, M., Li, L., Zhang, Y., Zhang, M., & Su, Z. (2020). Downregulated circular RNA zRANB1 mediates Wnt5a/β-Catenin signaling to promote neuropathic pain via miR-24-3p/LPAR3 axis in CCI rat models. Gene, 761, 145038.

Byrnes, C. C., Jia, W., Alshamrani, A. A., Kuppa, S. S., & Murph, M. M. (2019). miR-122-5p expression and secretion in melanoma cells is amplified by the LPAR3 SH3–binding domain to regulate Wnt1. Molecular Cancer Research, 17(1), 299-309.

Hua, X., Chen, J., & Wu, L. (2019). Identification of candidate biomarkers associated with apoptosis in melanosis coli: GNG5, LPAR3, MAPK8, and PSMC6. Bioscience reports, 39(1), BSR20181369.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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