LPAR3

This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.

Full Name

lysophosphatidic acid receptor 3

Function

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Bleb assemblyIEA:Ensembl
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Gene expressionIEA:Ensembl
Positive regulation of collateral sproutingIEA:Ensembl
Positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of MAPK cascadeIEA:Ensembl
Regulation of metabolic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-31
Helical: 32-52
Cytoplasmic: 53-67
Helical: 68-88
Extracellular: 89-101
Helical: 102-124
Cytoplasmic: 125-146
Helical: 147-167
Extracellular: 168-186
Helical: 187-207
Cytoplasmic: 208-240
Helical: 241-261
Extracellular: 262-276
Helical: 277-297
Cytoplasmic: 298-353