Mouse Anti-FBP2 Recombinant Antibody (1E10) (CBMAB-F0064-CQ)

Name: Mouse Anti-FBP2 Recombinant Antibody (1E10)
SKU: CBMAB-F0064-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1E10

Application

WB, ELISA

Immunogen

Recombinant human FBP2 (1-339aa) purified from E. coli

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fructose-Bisphosphatase 2

Introduction

This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate.

Entrez Gene ID

8789

UniProt ID

O00757

Alternative Names

Fructose-Bisphosphatase 2; D-Fructose-1,6-Bisphosphate 1-Phosphohydrolase 2; Fructose-1,6-Bisphosphatase 2; Muscle FBPase; EC 3.1.3.11; FBPase 2;

Research Area

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.

Biological Process

Fructose 1,6-bisphosphate metabolic process Source: GO_Central
Fructose 6-phosphate metabolic process Source: GO_Central
Fructose metabolic process Source: GO_Central
Gluconeogenesis Source: GO_Central
Sucrose biosynthetic process Source: GO_Central

Cellular Location

Cytoplasm; Nucleus; Cell junction; Z line. In neonatal cardiomyocytes, distributed throughout the cytosol, accumulating in the intercalated disks which occur at the Z line of cardiomyocytes and connect adjacent cells, and also located in the nucleus; dissociates from the Z line following an increase in cytosolic Ca2+ concentration (By similarity). In muscle precursor cells, localizes predominantly to the nucleus and to a lesser extent to the cytoplasm at the proliferative phase, while mainly localizing to the cytoplasm at the differentiation phase (By similarity). Colocalizes with ALDOA and alpha-actinin on both sides of the Z line of skeletal muscle; dissociates rapidly from the Z line following an increase in cytosolic Ca2+ concentration.

Duda, P., Janczara, J., McCubrey, J. A., Gizak, A., & Rakus, D. (2020). The reverse Warburg effect is associated with Fbp2-dependent Hif1α regulation in cancer cells stimulated by fibroblasts. Cells, 9(1), 205.

Bakshi, I., Suryana, E., Small, L., Quek, L. E., Brandon, A. E., Turner, N., & Cooney, G. J. (2018). Fructose bisphosphatase 2 overexpression increases glucose uptake in skeletal muscle. Journal of Endocrinology, 237(2), 101-111.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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