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Rat Anti-Fbxo32 Recombinant Antibody (CBT2446) (V2LY-0625-LY184)


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Summary

Host Animal
Rat
Specificity
Human
Clone
CBT2446
Antibody Isotype
IgG3
Application
FC

Basic Information

Immunogen
Synthesized peptide of human ATROGIN-1 (AA: 23-35).
Host Species
Rat
Specificity
Human
Antibody Isotype
IgG3
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
F-Box Protein 32
Entrez Gene ID
67731
UniProt ID
Q9CPU7
Research Area
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.
Biological Process
Cellular response to dexamethasone stimulus Source: Ensembl
Protein ubiquitination Source: UniProtKB
Response to denervation involved in regulation of muscle adaptation Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm. Shuttles between cytoplasm and the nucleus.
Involvement in disease
Defects in FBXO32 are associated with susceptibility to dilated cardiomyopathy (DCM). A disorder characterized by ventricular and impaired systolic function, resulting in heart failure and arrhythmia. Patient are at risk of premature death.
More Infomation

Xu, J., Shi, P., Xia, F., Zhao, X., Chen, J., Geng, R., ... & Yang, L. (2022). RAI14 Promotes Melanoma Progression by Regulating the FBXO32/c-MYC Pathway. International journal of molecular sciences, 23(19), 12036.

Ghasemi, S., Mahdavi, M., Maleki, M., Salahshourifar, I., & Kalayinia, S. (2022). A novel likely pathogenic variant in the FBXO32 gene associated with dilated cardiomyopathy according to whole‑exome sequencing. BMC Medical Genomics, 15(1), 1-8.

Zhang, N., Liao, Y., Lv, W., Zhu, S., Qiu, Y., Chen, N., ... & Zhang, H. (2022). FBXO32 targets PHPT1 for ubiquitination to regulate the growth of EGFR mutant lung cancer. Cellular Oncology, 45(2), 293-307.

Al-Yacoub, N., Colak, D., Mahmoud, S. A., Hammonds, M., Muhammed, K., Al-Harazi, O., ... & Poizat, C. (2021). Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis. Communications Biology, 4(1), 1-12.

Habel, N., El-Hachem, N., Soysouvanh, F., Hadhiri-Bzioueche, H., Giuliano, S., Nguyen, S., ... & Ballotti, R. (2021). FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells. Cell Death & Differentiation, 28(6), 1837-1848.

Bedada, F. B., Ntekim, O. E., Nwulia, E. O., Fungwe, T. V., Nadarajah, S. R., & Obisesan, T. O. (2021). Exercise Training-Increased FBXO32 and FOXO1 in a Gender-Dependent Manner in Mild Cognitively Impaired African Americans: GEMS-1 Study. Frontiers in Aging Neuroscience, 13, 641758.

Wang, H., Liu, H., Zhao, L., Luo, S., Akinyemiju, T., Hwang, S., ... & Wei, Q. (2021). Association of genetic variants of FBXO32 and FOXO6 in the FOXO pathway with breast cancer risk. Molecular carcinogenesis, 60(10), 661-670.

Shu, Y., Zhang, H., Li, J., & Shan, Y. (2021). LINC00494 Promotes Ovarian Cancer Development and Progression by Modulating NFκB1 and FBXO32. Frontiers in Oncology, 10, 541410.

Li, Y., Gao, S., Xue, W., Ma, Y., Meng, Y., & Zhang, D. (2021). miR-19a-3p Functions as an Oncogene by Regulating FBXO32 Expression in Multiple Myeloma. Balkan Medical Journal, 38(1), 43.

Wang, C., Li, X., Zhang, J., Ge, Z., Chen, H., & Hu, J. (2018). EZH2 contributes to 5-FU resistance in gastric cancer by epigenetically suppressing FBXO32 expression. OncoTargets and therapy, 11, 7853.

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For research use only. Not intended for any clinical use.

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