FBXO32

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Full Name
F-Box Protein 32
Research Area
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.
Biological Process
Cellular response to dexamethasone stimulus Source: Ensembl
Protein ubiquitination Source: UniProtKB
Response to denervation involved in regulation of muscle adaptation Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm. Shuttles between cytoplasm and the nucleus.
Involvement in disease
Defects in FBXO32 are associated with susceptibility to dilated cardiomyopathy (DCM). A disorder characterized by ventricular and impaired systolic function, resulting in heart failure and arrhythmia. Patient are at risk of premature death.
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Anti-FBXO32 antibodies

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Rabbit Anti-FBXO32 Recombinant Antibody (CAP745) (CBMAB-AP2218LY)

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Target: FBXO32
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP745
Application*: ICC, IF, WB
Datasheet SDS

Mouse Anti-FBXO32 Recombinant Antibody (1D6) (CBMAB-A2887-LY)

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Target: FBXO32
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D6
Application*: E, E
Datasheet SDS

Mouse Anti-FBXO32 Recombinant Antibody (CBXF-0406) (CBMAB-F3149-CQ)

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Target: FBXO32
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0406
Application*: E
Datasheet SDS

Mouse Anti-FBXO32 Recombinant Antibody (CBXF-0408) (CBMAB-F0359-CQ)

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Target: FBXO32
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0408
Application*: E
Datasheet SDS

Rabbit Anti-FBXO32 Recombinant Antibody (CBXF-1265) (CBMAB-F0206-CQ)

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Target: FBXO32
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-1265
Application*: WB, IF
Datasheet SDS

Rat Anti-Fbxo32 Recombinant Antibody (CBT2446) (V2LY-0625-LY184)

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Target: Fbxo32
Host: Rat
Antibody Isotype: IgG3
Specificity: Human
Clone: CBT2446
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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