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Rabbit Anti-FBXO32 Recombinant Antibody (CBXF-1265) (CBMAB-F0206-CQ)

This product is a rabbit antibody that recognizes FBXO32. The antibody CBXF-1265 can be used for immunoassay techniques such as: WB, IF.
See all FBXO32 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBXF-1265
Antibody Isotype
IgG
Application
WB, IF

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
F-Box Protein 32
Introduction
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
Human114907
Mouse67731
Rat171043
UniProt ID
HumanQ969P5
MouseQ9CPU7
RatQ91Z62
Alternative Names
F-Box Protein 32; Muscle Atrophy F-Box Protein; F-Box Only Protein 32; MAFbx; Atrogin 1; Atrogin-1; Fbx32;
Research Area
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.
Biological Process
Cellular response to dexamethasone stimulus Source: Ensembl
Protein ubiquitination Source: UniProtKB
Response to denervation involved in regulation of muscle adaptation Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm. Shuttles between cytoplasm and the nucleus.
Involvement in disease
Defects in FBXO32 are associated with susceptibility to dilated cardiomyopathy (DCM). A disorder characterized by ventricular and impaired systolic function, resulting in heart failure and arrhythmia. Patient are at risk of premature death.

Xu, J., Shi, P., Xia, F., Zhao, X., Chen, J., Geng, R., ... & Yang, L. (2022). RAI14 Promotes Melanoma Progression by Regulating the FBXO32/c-MYC Pathway. International journal of molecular sciences, 23(19), 12036.

Ghasemi, S., Mahdavi, M., Maleki, M., Salahshourifar, I., & Kalayinia, S. (2022). A novel likely pathogenic variant in the FBXO32 gene associated with dilated cardiomyopathy according to whole‑exome sequencing. BMC Medical Genomics, 15(1), 1-8.

Zhang, N., Liao, Y., Lv, W., Zhu, S., Qiu, Y., Chen, N., ... & Zhang, H. (2022). FBXO32 targets PHPT1 for ubiquitination to regulate the growth of EGFR mutant lung cancer. Cellular Oncology, 45(2), 293-307.

Al-Yacoub, N., Colak, D., Mahmoud, S. A., Hammonds, M., Muhammed, K., Al-Harazi, O., ... & Poizat, C. (2021). Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis. Communications Biology, 4(1), 1-12.

Habel, N., El-Hachem, N., Soysouvanh, F., Hadhiri-Bzioueche, H., Giuliano, S., Nguyen, S., ... & Ballotti, R. (2021). FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells. Cell Death & Differentiation, 28(6), 1837-1848.

Bedada, F. B., Ntekim, O. E., Nwulia, E. O., Fungwe, T. V., Nadarajah, S. R., & Obisesan, T. O. (2021). Exercise Training-Increased FBXO32 and FOXO1 in a Gender-Dependent Manner in Mild Cognitively Impaired African Americans: GEMS-1 Study. Frontiers in Aging Neuroscience, 13, 641758.

Wang, H., Liu, H., Zhao, L., Luo, S., Akinyemiju, T., Hwang, S., ... & Wei, Q. (2021). Association of genetic variants of FBXO32 and FOXO6 in the FOXO pathway with breast cancer risk. Molecular carcinogenesis, 60(10), 661-670.

Shu, Y., Zhang, H., Li, J., & Shan, Y. (2021). LINC00494 Promotes Ovarian Cancer Development and Progression by Modulating NFκB1 and FBXO32. Frontiers in Oncology, 10, 541410.

Li, Y., Gao, S., Xue, W., Ma, Y., Meng, Y., & Zhang, D. (2021). miR-19a-3p Functions as an Oncogene by Regulating FBXO32 Expression in Multiple Myeloma. Balkan Medical Journal, 38(1), 43.

Wang, C., Li, X., Zhang, J., Ge, Z., Chen, H., & Hu, J. (2018). EZH2 contributes to 5-FU resistance in gastric cancer by epigenetically suppressing FBXO32 expression. OncoTargets and therapy, 11, 7853.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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