Mouse Anti-FCAR Recombinant Antibody (CBXF-0436) (CBMAB-F2257-CQ)

Name: Mouse Anti-FCAR Recombinant Antibody (CBXF-0436)
SKU: CBMAB-F2257-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-0436

Application

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fc Fragment Of IgA Receptor

Introduction

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Entrez Gene ID

2204

UniProt ID

P24071

Alternative Names

Fc Fragment Of IgA Receptor; Fc Fragment Of IgA, Receptor For; CD89; Immunoglobulin Alpha Fc Receptor; Fc Alpha Receptor; FCAR Variant 14;

Research Area

Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.

Biological Process

Cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: CAFA
Cellular response to interferon-alpha Source: CAFA
Cellular response to interferon-gamma Source: CAFA
Cellular response to interleukin-6 Source: CAFA
Cellular response to lipopolysaccharide Source: CAFA
Cellular response to tumor necrosis factor Source: CAFA
Fc receptor signaling pathway Source: CAFA
Immune response Source: ProtInc
Neutrophil activation Source: CAFA
Neutrophil mediated immunity Source: CAFA
Positive regulation of neutrophil apoptotic process Source: CAFA
Positive regulation of oxidative stress-induced cell death Source: CAFA

Cellular Location

Isoform A.1&A.2&A.3: Cell membrane
Isoform B: Secreted
Isoform B-delta-S2: Secreted

Topology

Extracellular: 22-227
Helical: 228-246
Cytoplasmic: 247-287

Flowers, E. M., Neely, H. R., Guo, J., Almeida, T., Ohta, Y., Castro, C. D., & Flajnik, M. F. (2021). Identification of the Fc‐alpha/mu receptor in Xenopus provides insight into the emergence of the poly‐Ig receptor (pIgR) and mucosal Ig transport. European journal of immunology, 51(11), 2590-2606.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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