Mouse Anti-FCGR3B Recombinant Antibody (CBXF-2589) (CBMAB-F0133-CQ)

Name: Mouse Anti-FCGR3B Recombinant Antibody (CBXF-2589)
SKU: CBMAB-F0133-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-2589

Application

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.2 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fc Fragment Of IgG Receptor IIIb

Introduction

The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1.

Entrez Gene ID

2215

UniProt ID

O75015

Alternative Names

Fc Fragment Of IgG Receptor IIIb; Fc Fragment Of IgG, Low Affinity IIIb, Receptor (CD16b); Fc Gamma Receptor IIIb; IgG Fc Receptor III-1; Fc-Gamma RIII-Beta; Fc-Gamma RIIIb; FCRIIIb; FCR-10; FCRIII; FCGR3; CD16b;

Research Area

Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

Biological Process

Cell surface receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Regulation of immune response Source: GO_Central

Cellular Location

Cell membrane; Secreted. Secreted after cleavage.

PTM

Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3.
The soluble form is produced by a proteolytic cleavage.

Alyasova, A. V., Amoev, Z. V., Shkola, O. O., Novikov, D. V., Selivanova, S. G., & Novikov, V. V. (2022). Messenger RNA of FCGR3A and FCGR3B Genes as Monitoring Markers of Clear Cell Renal Adenocarcinoma (a Pilot Study). Современные технологии в медицине, 14(3 (eng)), 22-26.

Ines, M., Moalla, M., Aicha, B. T., Selma, B., Leila, R., Rawdha, T., ... & Imen, S. (2022). Impact of FCGR2A R131h, FCGR3A F158V and FCGR3B NA1/NA2 Polymorphisms on Response to Fc-Containing TNF Inhibitor in Rheumatoid Arthritis. FCGR3A F158V and FCGR3B NA1/NA2 Polymorphisms on Response to Fc-Containing TNF Inhibitor in Rheumatoid Arthritis (3/28/2022).

Nassir, N., Tambi, R., Bankapur, A., Al Heialy, S., Karuvantevida, N., Khansaheb, H. H., ... & Uddin, M. (2021). Single-cell transcriptome identifies FCGR3B upregulated subtype of alveolar macrophages in patients with critical COVID-19. Iscience, 24(9), 103030.

Alberici, F., Bonatti, F., Adorni, A., Daminelli, G., Sinico, R. A., Gregorini, G., ... & Vaglio, A. (2020). FCGR3B polymorphism predicts relapse risk in eosinophilic granulomatosis with polyangiitis. Rheumatology, 59(11), 3563-3566.

Dwomoh, D., Adu, B., Dodoo, D., Theisen, M., Iddi, S., & Gerds, T. A. (2020). Evaluating the predictive performance of malaria antibodies and FCGR3B gene polymorphisms on Plasmodium falciparum infection outcome: a prospective cohort study. Malaria Journal, 19(1), 1-12.

Kilani, B., Cornélis, F., Olaso, R., Chaudru, V., & Petit-Teixeira, E. (2019). Investigation of candidate gene copy number identifies FCGR3B as a potential biomarker for rheumatoid arthritis. Clinical and experimental rheumatology, 37(6), 923-928.

Dahmani, C. A., Benzaoui, A., Amroun, H., Zemani‐Fodil, F., Petit‐Teixeira, E., & Boudjema, A. (2019). Association study of copy number variants in CCL3L1, FCGR3A and FCGR3B genes with risk of ankylosing spondylitis in a West Algerian population. International Journal of Immunogenetics, 46(6), 437-443.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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