Mouse Anti-GP9 Recombinant Antibody (CBLG1-187) (CBMAB-G0661-LY)

Name: Mouse Anti-GP9 Recombinant Antibody (CBLG1-187)
SKU: CBMAB-G0661-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLG1-187

Application

Immunogen

Human red blood cells and platelets

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

lyophilized

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Glycoprotein IX Platelet

Entrez Gene ID

2815

UniProt ID

P14770

Alternative Names

Glycoprotein IX Platelet; Platelet Glycoprotein IX; Glycoprotein 9; GPIX; Glycoprotein IX (Platelet); CD42a Antigen; CD42a; GP-IX;

Function

The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.

Biological Process

Blood coagulation Source: ProtInc
Cell adhesion Source: ProtInc

Cellular Location

Membrane

Involvement in disease

Bernard-Soulier syndrome (BSS):
A coagulation disorder characterized by a prolonged bleeding time, unusually large platelets, thrombocytopenia, and impaired prothrombin consumption.

Topology

Extracellular: 17-147
Helical: 148-168
Cytoplasmic: 169-177

Gentilini, F., Turba, M. E., Giancola, F., Chiocchetti, R., Bernardini, C., Dajbychova, M., ... & Drögemüller, C. (2019). A large deletion in the GP9 gene in Cocker Spaniel dogs with Bernard-Soulier syndrome. Plos one, 14(9), e0220625.

Boisseau, P., Debord, C., Eveillard, M., Quéméner, A., Sigaud, M., Giraud, M., ... & Fouassier, M. (2018). Two novel variants of uncertain significance in GP9 associated with Bernard–Soulier syndrome: Are they true mutations?. Platelets, 29(3), 316-318.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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