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Mouse Anti-GPC5 Recombinant Antibody (297716) (CBMAB-G0687-LY)

This product is antibody recognizes GPC5. The antibody 297716 immunoassay techniques such as: FC.
See all GPC5 antibodies
Published Data
Fig.1 2-O-Sulfo-iduronic acid attached to glypican 5 in the EGL.
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Fig.2 Overexpression of GPC5 increases proliferation.
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Fig.3 Knockdown of GPC5 expression reduces cell proliferation in the rhabdomyosarcoma cell line RD.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
297716
Antibody Isotype
IgG2a
Application
FC

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glypican 5
Entrez Gene ID
Human2262
Mouse103978
UniProt ID
HumanP78333
MouseQ8CAL5
Function
Cell surface proteoglycan that bears heparan sulfate.
Biological Process
Cell migration Source: GO_Central
Positive regulation of canonical Wnt signaling pathway Source: GO_Central
Regulation of protein localization to membrane Source: GO_Central
Cellular Location
Cell membrane
Secreted glypican-5: Extracellular space

Bosworth, A. P., Contreras, M., Novak, S. W., Sancho, L., Salas, I. H., Manor, U., & Allen, N. J. (2023). Astrocyte glypican 5 regulates synapse maturation and stabilization. bioRxiv, 2023-03.

Takeuchi, M., Takeuchi, K., Takai, T., Yamaguchi, R., Furukawa, T., Akagi, K. I., & Takeuchi, J. K. (2021). Subcellular localization of glypican-5 is associated with dynamic motility of the human mesenchymal stem cell line U3DT. Plos one, 16(2), e0226538.

Schlaepfer Sales, C. B., Guimarães, V. S., Valverde, L. F., Dias, R. B., Freitas, R. D., Siquara da Rocha, L. D. O., ... & Gurgel Rocha, C. A. (2021). Glypican-1,-3,-5 (GPC1, GPC3, GPC5) and Hedgehog Pathway Expression in Oral Squamous Cell Carcinoma. Applied Immunohistochemistry & Molecular Morphology, 29(5), 345-351.

Yang, X., Chen, Y., Zhou, Y., Wu, C., Li, Q., Wu, J., ... & Ji, M. (2021). GPC5 suppresses lung cancer progression and metastasis via intracellular CTDSP1/AhR/ARNT signaling axis and extracellular exosome secretion. Oncogene, 40(25), 4307-4323.

Takeuchi, M., Takeuchi, K., Monobe, Y., Takai, T., Yamaguchi, R., Takeuchi, J. K., & Akagi, K. I. (2019). Subcellular localization of glypican-5 associates with dynamic cell motility and cell communication of the human mesenchymal stem cell line U3DT. bioRxiv, 863720.

Hong, X., Zhang, Z., Pan, L., Ma, W., Zhai, X., Gu, C., ... & Liu, Z. (2019). MicroRNA-301b promotes the proliferation and invasion of glioma cells through enhancing activation of Wnt/β-catenin signaling via targeting Glypican-5. European Journal of Pharmacology, 854, 39-47.

Yuan, Q., Zhang, Y., Li, J., Cao, G., & Yang, W. (2018). High expression of microRNA-4295 contributes to cell proliferation and invasion of pancreatic ductal adenocarcinoma by the down-regulation of Glypican-5. Biochemical and biophysical research communications, 497(1), 73-79.

Sun, Y., Xu, K., He, M., Fan, G., & Lu, H. (2018). Overexpression of glypican 5 (GPC5) inhibits prostate cancer cell proliferation and invasion via suppressing Sp1-mediated EMT and activation of Wnt/β-catenin signaling. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 26(4), 565-572.

Chui, M. H., Have, C., Hoang, L. N., Shaw, P., Lee, C. H., & Clarke, B. A. (2018). Genomic profiling identifies GPC5 amplification in association with sarcomatous transformation in a subset of uterine carcinosarcomas. The Journal of Pathology: Clinical Research, 4(1), 69-78.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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