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Mouse Anti-GPR15 Recombinant Antibody (SA302A10) (CBMAB-G0707-LY)

This product is antibody recognizes GPR15. The antibody SA302A10 immunoassay techniques such as: FC.
See all GPR15 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
SA302A10
Antibody Isotype
IgG2a, κ
Application
FC

Basic Information

Immunogen
Human GPR15-transfected cells
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.2% (w/v) BSA
Preservative
0.09% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G Protein-Coupled Receptor 15
Introduction
This gene encodes a G protein-coupled receptor that acts as a chemokine receptor for human immunodeficiency virus type 1 and 2. The encoded protein localizes to the cell membrane. [provided by RefSeq, Nov 2012]
Entrez Gene ID
2838
UniProt ID
P49685
Alternative Names
G Protein-Coupled Receptor 15; Brother Of Bonzo; BOB; G-Protein Coupled Receptor 15;
Function
Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.
Biological Process
G protein-coupled receptor signaling pathway Source: UniProtKB
T cell migration Source: Ensembl
Viral entry into host cell Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 1-33
Helical: 34-54
Cytoplasmic: 55-69
Helical: 70-90
Extracellular: 91-120
Helical: 121-141
Cytoplasmic: 142-149
Helical: 150-170
Extracellular: 171-192
Helical: 193-213
Cytoplasmic: 214-239
Helical: 240-260
Extracellular: 261-284
Helical: 285-305
Cytoplasmic: 306-360

Haase, T., Müller, C., Stoffers, B., Kirn, P., Waldenberger, M., Kaiser, F. J., ... & Zeller, T. (2022). G Protein-Coupled Receptor 15 Expression Is Associated with Myocardial Infarction. International Journal of Molecular Sciences, 24(1), 180.

Furukawa, K., Ling, J., Sun, Y., Lu, Y., Fu, J., Marukuchi, R., & Chiao, P. J. (2022). Recombinant Thrombomodulin Has Anti-tumor Effects and Enhances the Effects of Gemcitabine for Pancreatic Cancer Through G-protein Coupled Receptor 15. Anticancer research, 42(10), 4679-4687.

Deng, Y., Moo, E. V., Almería, C. V. P., Gentry, P. R., Vedel, L., Mathiesen, J. M., & Bräuner‐Osborne, H. (2022). Delineation of the GPR15 receptor‐mediated Gα protein signalling profile in recombinant mammalian cells. Basic & Clinical Pharmacology & Toxicology, 131(2), 104-113.

Bauer, M. (2021). The Role of GPR15 Function in Blood and Vasculature. International Journal of Molecular Sciences, 22(19), 10824.

Sezin, T., Jegodzinski, L., Meyne, L. M., Gupta, Y., Mousavi, S., Ludwig, R. J., ... & Sadik, C. D. (2021). The G protein‐coupled receptor 15 (GPR15) regulates cutaneous immunology by maintaining dendritic epidermal T cells and regulating the skin microbiome. European Journal of Immunology, 51(6), 1390-1398.

Guo, Y., Zhu, Q., Chen, S., Li, Y., Fu, D., Qiao, D., & Ni, C. (2021). Post-transcriptional suppression of G protein-coupled receptor 15 (GPR15) by microRNA-1225 inhibits proliferation, migration, and invasion of human colorectal cancer cells. 3 Biotech, 11(3), 139.

Jegodzinski, L., Sezin, T., Loser, K., Mousavi, S., Zillikens, D., & Sadik, C. D. (2020). The G protein-coupled receptor (GPR) 15 counteracts antibody-mediated skin inflammation. Frontiers in Immunology, 11, 1858.

Takeshita, A., Yasuma, T., Nishihama, K., D’Alessandro-Gabazza, C. N., Toda, M., Totoki, T., ... & Gabazza, E. C. (2020). Thrombomodulin ameliorates transforming growth factor-β1–mediated chronic kidney disease via the G-protein coupled receptor 15/Akt signal pathway. Kidney International, 98(5), 1179-1192.

Wang, Y., Wang, X., Xiong, Y., Li, C. D., Xu, Q., Shen, L., ... & Wei, D. Q. (2019). An integrated pan-cancer analysis and structure-based virtual screening of GPR15. International Journal of Molecular Sciences, 20(24), 6226.

Haase, T., Müller, C., Krause, J., Röthemeier, C., Stenzig, J., Kunze, S., ... & Zeller, T. (2018). Novel DNA methylation sites influence GPR15 expression in relation to smoking. Biomolecules, 8(3), 74.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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