Rabbit Anti-GPR37 Recombinant Antibody (CBLG1-1644) (CBMAB-G4660-LY)

Name: Rabbit Anti-GPR37 Recombinant Antibody (CBLG1-1644)
SKU: CBMAB-G4660-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBLG1-1644

Application

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

G Protein-Coupled Receptor 37

Introduction

This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]

Entrez Gene ID

Human	2861
Mouse	14763
Rat	117549

UniProt ID

Human	O15354
Mouse	Q9QY42
Rat	Q9QYC6

Function

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ParkinsonsUK-UCL
Dopamine biosynthetic process Source: Ensembl
G protein-coupled receptor signaling pathway Source: ProtInc
Locomotion involved in locomotory behavior Source: Ensembl
Negative regulation of hydrogen peroxide-induced cell death Source: ParkinsonsUK-UCL
Neuropeptide signaling pathway Source: UniProtKB
Positive regulation of dopamine metabolic process Source: Ensembl
Positive regulation of MAPK cascade Source: ParkinsonsUK-UCL

Cellular Location

Endoplasmic reticulum membrane; Cell membrane

Topology

Extracellular: 27-265
Helical: 266-286
Cytoplasmic: 287-299
Helical: 300-320
Extracellular: 321-335
Helical: 336-356
Cytoplasmic: 357-379
Helical: 380-400
Extracellular: 401-443
Helical: 444-464
Cytoplasmic: 465-493
Helical: 494-514
Extracellular: 515-531
Helical: 532-552
Cytoplasmic: 553-613

PTM

Ubiquitinated by PRKN in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death.

Sohel, M. S. H., Homma, T., Onouchi, S., & Saito, S. (2023). Expression patterns of prosaposin and its receptors, G protein–coupled receptor (GPR) 37 and GPR37L1 mRNAs, in the chick inner ear. Cell and Tissue Research, 1-17.

Fuyuki, A., Yamamoto, S., Sohel, M. S. H., Homma, T., Kitamura, K., Onouchi, S., & Saito, S. (2023). Expression of prosaposin and its G protein-coupled receptor (GPR) 37 in mouse cochlear and vestibular nuclei. Journal of Veterinary Medical Science, 85(3), 266-270.

Kitamura, K., Homma, T., Sohel, M. S. H., Fuyuki, A., Miyawaki, S., Onouchi, S., & Saito, S. (2023). Expression patterns of prosaposin and its receptors, G protein-coupled receptor (GPR) 37 and GPR37L1, in the mouse olfactory organ. Tissue and Cell, 82, 102093.

Marazziti, D. (2023). GPR37 and Related Receptors: Disease Regulation. International Journal of Molecular Sciences, 24(7), 6722.

He, F., Gao, F., Cai, N., Jiang, M., & Wu, C. (2022). Chlorogenic acid enhances alveolar macrophages phagocytosis in acute respiratory distress syndrome by activating G protein-coupled receptor 37 (GPR 37). Phytomedicine, 107, 154474.

Massimi, M., Di Pietro, C., La Sala, G., & Matteoni, R. (2022). Mouse Mutants of Gpr37 and Gpr37l1 Receptor Genes: Disease Modeling Applications. International Journal of Molecular Sciences, 23(8), 4288.

An, J., Zhang, Y., Fudge, A. D., Lu, H., Richardson, W. D., & Li, H. (2021). G protein‐coupled receptor GPR37‐like 1 regulates adult oligodendrocyte generation. Developmental Neurobiology, 81(8), 975-984.

Sarkar, S., Homma, T., Onouchi, S., Shimizu, Y., Shiina, T., Nabeka, H., ... & Saito, S. (2021). Expression of the G protein-coupled receptor (GPR) 37 and GPR37L1 in the mouse digestive system. Journal of Veterinary Medical Science, 83(1), 1-8.

Morato, X., Cunha, R. A., & Ciruela, F. (2019). G protein-coupled receptor 37 (GPR37) emerges as an important modulator of adenosinergic transmission in the striatum. Neural Regeneration Research, 14(11), 1912.

Jolly, S., Bazargani, N., Quiroga, A. C., Pringle, N. P., Attwell, D., Richardson, W. D., & Li, H. (2018). G protein‐coupled receptor 37‐like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia. Glia, 66(1), 47-61.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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