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Rabbit Anti-GPR37 Recombinant Antibody (D4C8H) (CBMAB-CP0862-LY)

The product is antibody recognizes GPR37. The antibody D4C8H immunoassay techniques such as: WB,IP.
See all GPR37 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D4C8H
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu590 of human GPR37 protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G Protein-Coupled Receptor 37
Introduction
This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]
Entrez Gene ID
Human2861
Mouse14763
Rat117549
UniProt ID
HumanO15354
MouseQ9QY42
RatQ9QYC6
Alternative Names
G Protein-Coupled Receptor 37; G Protein-Coupled Receptor 37 (Endothelin Receptor Type B-Like); Parkin-Associated Endothelin Receptor-Like Receptor; Endothelin B Receptor-Like Protein 1; ETBR-LP-1; PAELR; Probable G-Protein Coupled Receptor 37;
Function
Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ParkinsonsUK-UCL
Dopamine biosynthetic process Source: Ensembl
G protein-coupled receptor signaling pathway Source: ProtInc
Locomotion involved in locomotory behavior Source: Ensembl
Negative regulation of hydrogen peroxide-induced cell death Source: ParkinsonsUK-UCL
Neuropeptide signaling pathway Source: UniProtKB
Positive regulation of dopamine metabolic process Source: Ensembl
Positive regulation of MAPK cascade Source: ParkinsonsUK-UCL
Cellular Location
Endoplasmic reticulum membrane; Cell membrane
Topology
Extracellular: 27-265
Helical: 266-286
Cytoplasmic: 287-299
Helical: 300-320
Extracellular: 321-335
Helical: 336-356
Cytoplasmic: 357-379
Helical: 380-400
Extracellular: 401-443
Helical: 444-464
Cytoplasmic: 465-493
Helical: 494-514
Extracellular: 515-531
Helical: 532-552
Cytoplasmic: 553-613
PTM
Ubiquitinated by PRKN in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death.

Sohel, M. S. H., Homma, T., Onouchi, S., & Saito, S. (2023). Expression patterns of prosaposin and its receptors, G protein–coupled receptor (GPR) 37 and GPR37L1 mRNAs, in the chick inner ear. Cell and Tissue Research, 1-17.

Fuyuki, A., Yamamoto, S., Sohel, M. S. H., Homma, T., Kitamura, K., Onouchi, S., & Saito, S. (2023). Expression of prosaposin and its G protein-coupled receptor (GPR) 37 in mouse cochlear and vestibular nuclei. Journal of Veterinary Medical Science, 85(3), 266-270.

Kitamura, K., Homma, T., Sohel, M. S. H., Fuyuki, A., Miyawaki, S., Onouchi, S., & Saito, S. (2023). Expression patterns of prosaposin and its receptors, G protein-coupled receptor (GPR) 37 and GPR37L1, in the mouse olfactory organ. Tissue and Cell, 82, 102093.

Marazziti, D. (2023). GPR37 and Related Receptors: Disease Regulation. International Journal of Molecular Sciences, 24(7), 6722.

He, F., Gao, F., Cai, N., Jiang, M., & Wu, C. (2022). Chlorogenic acid enhances alveolar macrophages phagocytosis in acute respiratory distress syndrome by activating G protein-coupled receptor 37 (GPR 37). Phytomedicine, 107, 154474.

Massimi, M., Di Pietro, C., La Sala, G., & Matteoni, R. (2022). Mouse Mutants of Gpr37 and Gpr37l1 Receptor Genes: Disease Modeling Applications. International Journal of Molecular Sciences, 23(8), 4288.

An, J., Zhang, Y., Fudge, A. D., Lu, H., Richardson, W. D., & Li, H. (2021). G protein‐coupled receptor GPR37‐like 1 regulates adult oligodendrocyte generation. Developmental Neurobiology, 81(8), 975-984.

Sarkar, S., Homma, T., Onouchi, S., Shimizu, Y., Shiina, T., Nabeka, H., ... & Saito, S. (2021). Expression of the G protein-coupled receptor (GPR) 37 and GPR37L1 in the mouse digestive system. Journal of Veterinary Medical Science, 83(1), 1-8.

Morato, X., Cunha, R. A., & Ciruela, F. (2019). G protein-coupled receptor 37 (GPR37) emerges as an important modulator of adenosinergic transmission in the striatum. Neural Regeneration Research, 14(11), 1912.

Jolly, S., Bazargani, N., Quiroga, A. C., Pringle, N. P., Attwell, D., Richardson, W. D., & Li, H. (2018). G protein‐coupled receptor 37‐like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia. Glia, 66(1), 47-61.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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