Mouse Anti-GSC Recombinant Antibody (14i160) (CBMAB-G5104-LY)

Name: Mouse Anti-GSC Recombinant Antibody (14i160)
SKU: CBMAB-G5104-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

14i160

Application

ELISA, FC

Immunogen

Recombinant protein corresponding to aa191-257 from human GSC expressed in E. coli

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.5% protein stabilizer

Preservative

0.05% sodium azide

Concentration

1 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Goosecoid Homeobox

Introduction

This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. [provided by RefSeq, Jul 2008]

Entrez Gene ID

145258

UniProt ID

P56915

Alternative Names

Goosecoid Homeobox; Homeobox Protein Goosecoid; SAMS;

Function

Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity).

Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals.

Biological Process

Dorsal/ventral neural tube patterning Source: Ensembl
Embryonic skeletal system morphogenesis Source: Ensembl
Forebrain development Source: Ensembl
Gastrulation Source: UniProtKB
Middle ear morphogenesis Source: UniProtKB
Muscle organ morphogenesis Source: Ensembl
Negative regulation of Wnt signaling pathway Source: Ensembl
Neural crest cell fate specification Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Signal transduction involved in regulation of gene expression Source: Ensembl

Cellular Location

Nucleus

Involvement in disease

Short stature, auditory canal atresia, mandibular hypoplasia, skeletal abnormalities (SAMS):
An autosomal recessive developmental disorder with features of a first and second branchial arch syndrome, and with unique rhizomelic skeletal anomalies. Craniofacial abnormalities can lead to conductive hearing loss, respiratory insufficiency, and feeding difficulties. Skeletal features include bilateral humeral hypoplasia, humeroscapular synostosis, pelvic abnormalities, and proximal defects of the femora. Affected individuals may also have some features of a neurocristopathy or abnormal mesoderm development, such as urogenital anomalies, that are distinct from other branchial arch syndromes.

Kumar, V., Umair, Z., Lee, U., & Kim, J. (2023). Two Homeobox Transcription Factors, Goosecoid and Ventx1. 1, Oppositely Regulate Chordin Transcription in Xenopus Gastrula Embryos. Cells, 12(6), 874.

Umair, Z., Kumar, V., Goutam, R. S., Kumar, S., Lee, U., & Kim, J. (2021). Goosecoid Controls Neuroectoderm Specification via Dual Circuits of Direct Repression and Indirect Stimulation in Xenopus Embryos. Molecules and Cells, 44(10), 723.

Yasuoka, Y., Tando, Y., Kubokawa, K., & Taira, M. (2019). Evolution of cis-regulatory modules for the head organizer gene goosecoid in chordates: comparisons between Branchiostoma and Xenopus. Zoological Letters, 5(1), 1-17.

Liu, F., Fu, Q., Li, Y., Zhang, K., Tang, M., Jiang, W., ... & Kong, L. (2019). USP21 modulates Goosecoid function through deubiquitination. Bioscience Reports, 39(7).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

GSC Matched Antibody Pair (503) (CAT#: APMAB-503LY)

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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