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Mouse Anti-GSPT2 Recombinant Antibody (CBLG1-2998) (CBMAB-G5305-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-2998
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human GSPT2 (NP_060564) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% NaN3
Concentration
0.32 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G1 To S Phase Transition 2
Introduction
This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability.[provided by RefSeq, Mar 2010]
Entrez Gene ID
23708
UniProt ID
Q8IYD1
Alternative Names
G1 To S Phase Transition 2; Eukaryotic Peptide Chain Release Factor Subunit 3b; ERF3B; Eukaryotic Peptide Chain Release Factor GTP-Binding Subunit ERF3B; G1 To S Phase Transition Protein 2 Homolog; GST2;
Function
Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
Biological Process
Cell cycle Source: UniProtKB-KW
Cytoplasmic translational termination Source: GO_Central
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB-KW
Translation Source: GO_Central
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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