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Mouse Anti-GSR Recombinant Antibody (AT11D10) (CBMAB-H1384-FY)

This product is mouse antibody that recognizes GSR. The antibody AT11D10 can be used for immunoassay techniques such as: ELISA, WB.
See all GSR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
AT11D10
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.02% Sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
glutathione reductase
Introduction
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
Entrez Gene ID
2936
UniProt ID
P00390
Alternative Names
Glutathione-Disulfide Reductase; Glutathione S-Reductase; EC 1.8.1.7; GRase; GR; Epididymis Secretory Sperm Binding Protein Li 122m; Glutathione Reductase, Mitochondrial; Epididymis Luminal Protein 75
Function
Maintains high levels of reduced glutathione in the cytosol.
Biological Process
Cell redox homeostasis Source: GO_Central
Cellular response to oxidative stress Source: GO_Central
Glutathione metabolic process Source: GO_Central
Cellular Location
Isoform Mitochondrial: Mitochondrion
Isoform Cytoplasmic: Cytoplasm
Involvement in disease
Hemolytic anemia due to glutathione reductase deficiency (HAGRD):
An autosomal recessive disease characterized by hemolytic anemia and impaired activity of glutathione reductase. Patients experience hemolytic anemia in response to oxidative stress or ingestion of fava beans.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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