Mouse Anti-GSR Recombinant Antibody (CBLG1-1932) (CBMAB-G5325-LY)

Name: Mouse Anti-GSR Recombinant Antibody (CBLG1-1932)
SKU: CBMAB-G5325-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLG1-1932

Application

Immunogen

Glutathione Reductase

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50% glycerol

Preservative

0.02% NaN3

Concentration

0.5 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

glutathione reductase

Introduction

This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]

Entrez Gene ID

2936

UniProt ID

P00390

Alternative Names

Glutathione-Disulfide Reductase; Glutathione S-Reductase; EC 1.8.1.7; GRase; GR; Epididymis Secretory Sperm Binding Protein Li 122m; Glutathione Reductase; Mitochondrial; Epididymis Luminal Protein 75;

Function

Maintains high levels of reduced glutathione in the cytosol.

Biological Process

Cell redox homeostasis Source: GO_Central
Cellular response to oxidative stress Source: GO_Central
Glutathione metabolic process Source: GO_Central

Cellular Location

Isoform Mitochondrial: Mitochondrion
Isoform Cytoplasmic: Cytoplasm

Involvement in disease

Hemolytic anemia due to glutathione reductase deficiency (HAGRD):
An autosomal recessive disease characterized by hemolytic anemia and impaired activity of glutathione reductase. Patients experience hemolytic anemia in response to oxidative stress or ingestion of fava beans.

Xu, C., Luo, M., Liu, X., Wei, T., Zhou, Z., Li, C., ... & Sui, H. (2023). MicroRNA-1298-5p in granulosa cells facilitates cell autophagy in polycystic ovary syndrome by suppressing glutathione-disulfide reductase. Cell and Tissue Research, 1-16.

Zhang, C., & Zhao, D. (2021). MicroRNA-362-5p promotes the proliferation and inhibits apoptosis of trophoblast cells via targeting glutathione-disulfide reductase. Bioengineered, 12(1), 2410-2419.

Johnson, F. D., Ferrarone, J., Liu, A., Brandstädter, C., Munuganti, R., Farnsworth, D., ... & Lockwood, W. W. (2021). A novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1. bioRxiv, 2021-06.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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