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Mouse Anti-GSTZ1 Recombinant Antibody (CBLG1-272) (CBMAB-G0918-LY)

This product is antibody recognizes GSTZ1. The antibody CBLG1-272 immunoassay techniques such as: ELISA, ICC, WB.
See all GSTZ1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-272
Antibody Isotype
IgG2b
Application
ELISA, ICC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.09% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Glutathione S-Transferase Zeta 1
Introduction
This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme catalyzes the conversion of maleylacetoacetate to fumarylacetoacatate, which is one of the steps in the phenylalanine/tyrosine degradation pathway. Deficiency of a similar gene in mouse causes oxidative stress. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq, Jul 2015]
Entrez Gene ID
2954
UniProt ID
O43708
Alternative Names
Glutathione S-Transferase Zeta 1; Glutathione Transferase Zeta 1; Maleylacetoacetate Isomerase; GSTZ1-1; MAAI; S-(Hydroxyalkyl)Glutathione Lyase; Glutathione S-Aralkyltransferase; Glutathione S-Alkyltransferase;
Function
Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid.
Biological Process
Glutathione metabolic process Source: UniProtKB
L-phenylalanine catabolic process Source: GO_Central
Tyrosine catabolic process Source: UniProtKB-KW
Cellular Location
Cytoplasm
Involvement in disease
Maleylacetoacetate isomerase deficiency (MAAID):
An autosomal recessive inborn error of metabolism characterized by mild elevations in succinylacetone in blood and urine, usually identified by newborn screening. Liver function and coagulation are normal. MAAID is a benign disorder.

Liao, Y., Chin Chan, S., Welsh, E. A., Fang, B., Sun, L., Schönbrunn, E., ... & Rix, U. (2023). Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target. ACS Chemical Biology.

Wang, Q., Bin, C., Xue, Q., Gao, Q., Huang, A., Wang, K., & Tang, N. (2021). GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis. Cell death & disease, 12(5), 426.

Alaidaroos, N. Y., Alraies, A., Waddington, R. J., Sloan, A. J., & Moseley, R. (2021). Differential SOD2 and GSTZ1 profiles contribute to contrasting dental pulp stem cell susceptibilities to oxidative damage and premature senescence. Stem Cell Research & Therapy, 12(1), 1-19.

Lei, C., Wang, Q., Tang, N., & Wang, K. (2020). GSTZ1‐1 downregulates Wnt/β‐catenin signalling in hepatocellular carcinoma cells. FEBS Open bio, 10(1), 6-17.

Li, J., Wang, Q., Yang, Y., Lei, C., Yang, F., Liang, L., ... & Tang, N. (2019). GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway. Journal of Experimental & Clinical Cancer Research, 38(1), 1-17.

Yang, F., Li, J., Deng, H., Wang, Y., Lei, C., Wang, Q., ... & Tang, N. (2019). GSTZ 1‐1 Deficiency Activates NRF 2/IGF 1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone. The EMBO Journal, 38(15), e101964.

Yang, P., Cao, W. C., Zhou, B., Zheng, T. Z., Deng, Y. L., Luo, Q., ... & Lu, W. Q. (2019). Urinary biomarker of prenatal exposure to disinfection byproducts, maternal genetic polymorphisms in CYP2E1 and GSTZ1, and birth outcomes. Environmental Science & Technology, 53(20), 12026-12034.

Tian, D. D., Bennett, S. K., Coupland, L. A., Forwood, K., Lwin, Y., Pooryousef, N., ... & Blackburn, A. C. (2019). GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial. Pharmacology research & perspectives, 7(6), e00526.

Langaee, T., Wagner, R., Horne, L. P., Lawson, L. A., Becker, C., Shahin, M., ... & Stacpoole, P. W. (2018). Personalized dosing of dichloroacetate using GSTZ1 clinical genotyping assay. Genetic testing and molecular biomarkers, 22(4), 266-269.

Zhou, B., Yang, P., Gong, Y. J., Zeng, Q., Lu, W. Q., & Miao, X. P. (2018). Effect modification of CPY2E1 and GSTZ1 genetic polymorphisms on associations between prenatal disinfection by-products exposure and birth outcomes. Environmental Pollution, 243, 1126-1133.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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