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Mouse Anti-GTF2A1L Recombinant Antibody (4F5) (CBMAB-G5646-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4F5
Antibody Isotype
IgG1, κ
Application
ELISA, IP, WB

Basic Information

Immunogen
ALF (NP_006863, 251 a.a. ~ 348 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: PQVSQTNSNV ESVLSGSASM AQNLHDESLS TSPHGALHQH VTDIQLHILK NRMYGCDSVK QPRNIEEPSN IPVSEKDSNS QVDLSIRVTD DDIGEIIQ
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
General Transcription Factor IIA Subunit 1 Like
Introduction
The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of transcription factor IIA (TFIIA) on the interaction between TATA-binding protein (TBP) and DNA. This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Mar 2014]
Entrez Gene ID
11036
UniProt ID
Q9UNN4
Alternative Names
General Transcription Factor IIA Subunit 1 Like; General Transcription Factor II A; 1-Like Factor; ALF; Testis Secretory Sperm-Binding Protein Li 230m; General Transcription Factor IIA; 1-Like; General Transcription Factor IIA 1 Like; General Transcription Factor IIA 1-Like;
Function
May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription.
Biological Process
Cognition Source: UniProtKB
Transcription by RNA polymerase II Source: GO_Central
Transcription initiation from RNA polymerase II promoter Source: InterPro
Cellular Location
Nucleus. Mainly localizes in the annulus and partly in acrosomal cap area of spermatozoa.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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