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Mouse Anti-GTF2H1 Antibody (1A10) (CBMAB-0427-YC)

Provided herein are mouse monoclonal antibodies against Human GTF2H1. The antibody clone 1A10 can be used for immunoassay techniques, such as ELISA and IP.
See all GTF2H1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A10
Antibody Isotype
IgG2c
Application
ELISA, IP

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2c
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
general transcription factor IIH subunit 1
Introduction
GTF2H1 (general transcription factor IIH subunit 1) is a protein that in humans is encoded by the GTF2H1 gene. GTF2H1 has been shown to interact with Cyclin-dependent kinase 7,E2F1 and ERCC2.
Entrez Gene ID
2965
UniProt ID
P32780
Alternative Names
BTF2; P62; TFIIH
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Biological Process
DNA repair Source: GO_Central
Hormone-mediated signaling pathway Source: UniProtKB
Nucleotide-excision repair Source: InterPro
Phosphorylation of RNA polymerase II C-terminal domain Source: GO_Central
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Transcription by RNA polymerase I Source: GO_Central
Transcription by RNA polymerase II Source: UniProtKB
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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