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GTF2H1

GTF2H1 (General Transcription Factor IIH Subunit 1) is a Protein Coding gene. Diseases associated with GTF2H1 include Rift Valley Fever and Cockayne Syndrome. Among its related pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include protein kinase activity and RNA polymerase II CTD heptapeptide repeat kinase activity.
Full Name
general transcription factor IIH subunit 1
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Biological Process
DNA repair Source: GO_Central
Hormone-mediated signaling pathway Source: UniProtKB
Nucleotide-excision repair Source: InterPro
Phosphorylation of RNA polymerase II C-terminal domain Source: GO_Central
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Transcription by RNA polymerase I Source: GO_Central
Transcription by RNA polymerase II Source: UniProtKB
Cellular Location
Nucleus
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Anti-GTF2H1 antibodies

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Mouse Anti-GTF2H1 Recombinant Antibody (EG1464) (CBMAB-EN1750-LY)

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Target: GTF2H1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: EG1464
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-GTF2H1 Recombinant Antibody (CAP873) (CBMAB-AP2648LY)

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Target: GTF2H1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP873
Application*: IP, WB
Datasheet SDS

Mouse Anti-GTF2H1 Recombinant Antibody (CAP872) (CBMAB-AP2647LY)

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Target: GTF2H1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Human, Mouse, Pig, Rat
Clone: CAP872
Application*: ELISA, ICC, WB
Datasheet SDS

Mouse Anti-GTF2H1 Recombinant Antibody (CB434A) (CBMAB-CA434LY)

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Target: GTF2H1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Human, Mouse, Pig, Rat
Clone: CB434A
Application*: ELISA, WB, ICC
Datasheet SDS

Mouse Anti-GTF2H1 Recombinant Antibody (CBLG1-2116) (CBMAB-G5706-LY)

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Target: GTF2H1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2116
Application*: WB
Datasheet SDS

Mouse Anti-GTF2H1 Recombinant Antibody (CBLG1-2115) (CBMAB-G5705-LY)

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Target: GTF2H1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human
Clone: CBLG1-2115
Application*: WB
Datasheet SDS

Mouse Anti-GTF2H1 Recombinant Antibody (CBLG1-2114) (CBMAB-G5704-LY)

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Target: GTF2H1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2114
Application*: E (IA), WB
Datasheet SDS

Mouse Anti-GTF2H1 Recombinant Antibody (CBLG1-2113) (CBMAB-G5703-LY)

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Target: GTF2H1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2113
Application*: IP, WB
Datasheet SDS

Mouse Anti-GTF2H1 Recombinant Antibody (360C5a) (CBMAB-G5699-LY)

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Target: GTF2H1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 360C5a
Application*: DB, IP, WB
Datasheet SDS

Mouse Anti-GTF2H1 Recombinant Antibody (1F12-1B5) (CBMAB-G5698-LY)

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Target: GTF2H1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F12-1B5
Application*: WB
Datasheet SDS

Mouse Anti-GTF2H1 Recombinant Antibody (13k61) (CBMAB-G5696-LY)

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Target: GTF2H1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13k61
Application*: IP, WB
Datasheet SDS

Mouse Anti-GTF2H1 Recombinant Antibody (CBT1198) (V2LY-0625-LY2952)

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Target: GTF2H1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle, Dog, Pig
Clone: CBT1198
Application*: WB
Datasheet SDS

Mouse Anti-GTF2H1 Recombinant Antibody (CBYJT-1324) (CBMAB-T0340-YJ)

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Target: GTF2H1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-1324
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-GTF2H1 Recombinant Antibody (CBYJT-1323) (CBMAB-T0339-YJ)

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Target: GTF2H1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1323
Application*: E, IF, P, WB
Datasheet SDS

Mouse Anti-GTF2H1 Recombinant Antibody (CBYJT-1322) (CBMAB-T0338-YJ)

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Target: GTF2H1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1322
Application*: DB, IP, WB
Datasheet SDS

Mouse Anti-GTF2H1 Recombinant Antibody (CBYJT-1321) (CBMAB-T0337-YJ)

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Target: GTF2H1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-1321
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-GTF2H1 Antibody (1A10) (CBMAB-0427-YC)

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Target: GTF2H1
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 1A10
Application*: E, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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