GTF2H1

GTF2H1 (General Transcription Factor IIH Subunit 1) is a Protein Coding gene. Diseases associated with GTF2H1 include Rift Valley Fever and Cockayne Syndrome. Among its related pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include protein kinase activity and RNA polymerase II CTD heptapeptide repeat kinase activity.

general transcription factor IIH subunit 1

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.

DNA repair Source: GO_Central
Hormone-mediated signaling pathway Source: UniProtKB
Nucleotide-excision repair Source: InterPro
Phosphorylation of RNA polymerase II C-terminal domain Source: GO_Central
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Transcription by RNA polymerase I Source: GO_Central
Transcription by RNA polymerase II Source: UniProtKB

Nucleus