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Mouse Anti-GTF2H1 Recombinant Antibody (CAP872) (CBMAB-AP2647LY)


See all GTF2H1 antibodies

Summary

Host Animal
Mouse
Specificity
Dog, Human, Mouse, Pig, Rat
Clone
CAP872
Antibody Isotype
IgG1
Application
ELISA, ICC, WB

Basic Information

Immunogen
Recombinant fragment, corresponding to amino acids 1aa-279aa of human GTF2H1 (N-terminus).
Specificity
Dog, Human, Mouse, Pig, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
general transcription factor IIH subunit 1
Introduction
GTF2H1 (General Transcription Factor IIH Subunit 1) is a Protein Coding gene. Diseases associated with GTF2H1 include Rift Valley Fever and Cockayne Syndrome. Among its related pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include protein kinase activity and RNA polymerase II CTD heptapeptide repeat kinase activity.
Entrez Gene ID
Human2965
Mouse14884
Rat361580
Dog476881
Pig100525504
UniProt ID
HumanP32780
MouseQ9DBA9
RatD3ZYG3
DogE2RCX0
PigF1S9C2
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Biological Process
DNA repair Source: GO_Central
Hormone-mediated signaling pathway Source: UniProtKB
Nucleotide-excision repair Source: InterPro
Phosphorylation of RNA polymerase II C-terminal domain Source: GO_Central
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Transcription by RNA polymerase I Source: GO_Central
Transcription by RNA polymerase II Source: UniProtKB
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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