Mouse Anti-GTF3A Recombinant Antibody (CBFYH-0536) (CBMAB-H1416-FY)

Name: Mouse Anti-GTF3A Recombinant Antibody (CBFYH-0536)
SKU: CBMAB-H1416-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-0536

Application

ELISA, ELISA(Cap), WB

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

General Transcription Factor IIIA

Introduction

The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein.

Entrez Gene ID

2971

UniProt ID

Q92664

Alternative Names

General Transcription Factor IIIA; TFIIIA; Transcription Factor IIIA; AP2

Function

Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (PubMed:24120868).

Also binds the transcribed 5S RNA's (By similarity).

Biological Process

Ribosomal large subunit biogenesis Source: UniProtKB
rRNA transcription Source: ProtInc
Transcription by RNA polymerase III Source: ProtInc

Cellular Location

Nucleus

Bordon, Y. (2023). GTF3A mutations impair antiviral immunity. Nature Reviews Immunology, 23(1), 4-4.

Naesens, L., Muppala, S., Acharya, D., Nemegeer, J., Bogaert, D., Lee, J. H., ... & Haerynck, F. (2022). GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141. Science Immunology, 7(77), eabq4531.

Naesens, L. (2022). GTF3A deficiency in humans predisposes to herpes simplex encephalitis by abrogating transcription of the host-derived RIG-I ligand RNA5SP141. In Florida International University-Center for Translational Science Research Symposium.

Naesens, L. (2022). GTF3A deficiency predisposes to invasive HSV-1 encephalitis by abrogated transcription of a host RIG-I ligand. In European Society for Immunodeficiencies.

Naesens, L., Muppala, S., Lee, J. H., Nemegeer, J., Acharya, D., Bogaert, D., ... & Haerynck, F. (2021). GTF3A mutations in a patient with herpes simplex encephalitis reveals a novel role in viral immunity by transcribing 5S rRNA pseudogenes serving as RIG-I ligands. In VIB Translational Immunology.

Rojo-Bartolomé, I., Santana de Souza, J. E., Diaz de Cerio, O., & Cancio, I. (2020). Duplication and subfunctionalisation of the general transcription factor IIIA (gtf3a) gene in teleost genomes, with ovarian specific transcription of gtf3ab. Plos one, 15(1), e0227690.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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