Mouse Anti-HSPB2 Recombinant Antibody (CBT3183) (V2LY-0625-LY223)

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Tested Data
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBT3183
Application
FC
Immunogen
Purified recombinant fragment of human HSPB2 (AA: 1-182) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
heat shock protein family B (small) member 2
Entrez Gene ID
UniProt ID
Function
May regulate the kinase DMPK.
Biological Process
Response to unfolded protein Source: ProtInc
Cellular Location
Cytoplasm; Nucleus. Localizes to nuclear foci.

Huang, Y., Meng, S., Wu, B., Shi, H., Wang, Y., Xiang, J., ... & Gao, Y. (2023). HSPB2 facilitates neural regeneration through autophagy for sensorimotor recovery after traumatic brain injury. JCI insight, 8(16).

Gianniou, D. D., Sklirou, A. D., Papadimitriou, M. A., Pilala, K. M., Stravodimos, K., Avgeris, M., ... & Trougakos, I. P. (2023). Evaluation of the Small Heat Shock Protein Family Members HSPB2 and HSPB3 in Bladder Cancer Prognosis and Progression. International Journal of Molecular Sciences, 24(3), 2609.

Li, A., Chen, A. J., Xu, J., Wen, Z. Y., Bai, G. L., Wang, Z. Y., ... & Wang, P. (2023). Rapamycin Protects Mouse Skin from Ultraviolet B-Induced Photodamage by Modulating Hspb2-Mediated Autophagy and Apoptosis.

Sklirou, A. D., Gianniou, D. D., Karousi, P., Cheimonidi, C., Papachristopoulou, G., Kontos, C. K., ... & Trougakos, I. P. (2022). High mRNA expression levels of heat shock protein family B member 2 (HSPB2) are associated with breast cancer patients’ relapse and poor survival. International Journal of Molecular Sciences, 23(17), 9758.

Yu, W., Wang, J., Li, C., Xuan, M., Han, S., Zhang, Y., ... & Zhao, Z. (2022). miR-17-5p promotes the invasion and migration of colorectal cancer by regulating HSPB2. Journal of Cancer, 13(3), 918.

Gou, D., Zhou, J., Song, Q., Wang, Z., Bai, X., Zhang, Y., ... & Wang, Q. (2021). Mog1 knockout causes cardiac hypertrophy and heart failure by downregulating tbx5‐cryab‐hspb2 signalling in zebrafish. Acta Physiologica, 231(3), e13567.

Wang, L., Wang, F., Liu, K., Long, C., Chen, Y., Li, C., ... & Zhang, H. (2021). αB‐crystallin/HSPB2 is critical for hyperactive mTOR‐induced cardiomyopathy. Journal of Cellular Physiology, 236(12), 8110-8121.

Yu, Z., Wang, H., Fang, Y., Lu, L., Li, M., Yan, B., ... & Teng, C. (2020). Molecular chaperone HspB2 inhibited pancreatic cancer cell proliferation via activating p53 downstream gene RPRM, BAI1, and TSAP6. Journal of cellular biochemistry, 121(3), 2318-2329.

Kim, N., Yu, L., Dawe, R., Petyuk, V. A., Gaiteri, C., De Jager, P. L., ... & Bennett, D. A. (2019). Microstructural changes in the brain mediate the association of AK4, IGFBP5, HSPB2, and ITPK1 with cognitive decline. Neurobiology of aging, 84, 17-25.

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For research use only. Not intended for any clinical use.

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