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Rabbit Anti-HSPB2 Recombinant Antibody (EG1583) (CBMAB-EN1895-LY)

The product is antibody recognizes HSPB2. The antibody EG1583 immunoassay techniques such as: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:40000.
See all HSPB2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG1583
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human HSPB2.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
heat shock protein family B (small) member 2
Introduction
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function.
Entrez Gene ID
Human3316
Mouse69253
Rat161476
UniProt ID
HumanQ16082
MouseQ99PR8
RatO35878
Alternative Names
MKBP; HSP27; Hs.78846; LOH11CR1K
Function
May regulate the kinase DMPK.
Biological Process
Response to unfolded protein Source: ProtInc
Cellular Location
Cytoplasm; Nucleus. Localizes to nuclear foci.

Huang, Y., Meng, S., Wu, B., Shi, H., Wang, Y., Xiang, J., ... & Gao, Y. (2023). HSPB2 facilitates neural regeneration through autophagy for sensorimotor recovery after traumatic brain injury. JCI insight, 8(16).

Gianniou, D. D., Sklirou, A. D., Papadimitriou, M. A., Pilala, K. M., Stravodimos, K., Avgeris, M., ... & Trougakos, I. P. (2023). Evaluation of the Small Heat Shock Protein Family Members HSPB2 and HSPB3 in Bladder Cancer Prognosis and Progression. International Journal of Molecular Sciences, 24(3), 2609.

Li, A., Chen, A. J., Xu, J., Wen, Z. Y., Bai, G. L., Wang, Z. Y., ... & Wang, P. (2023). Rapamycin Protects Mouse Skin from Ultraviolet B-Induced Photodamage by Modulating Hspb2-Mediated Autophagy and Apoptosis.

Sklirou, A. D., Gianniou, D. D., Karousi, P., Cheimonidi, C., Papachristopoulou, G., Kontos, C. K., ... & Trougakos, I. P. (2022). High mRNA expression levels of heat shock protein family B member 2 (HSPB2) are associated with breast cancer patients’ relapse and poor survival. International Journal of Molecular Sciences, 23(17), 9758.

Yu, W., Wang, J., Li, C., Xuan, M., Han, S., Zhang, Y., ... & Zhao, Z. (2022). miR-17-5p promotes the invasion and migration of colorectal cancer by regulating HSPB2. Journal of Cancer, 13(3), 918.

Gou, D., Zhou, J., Song, Q., Wang, Z., Bai, X., Zhang, Y., ... & Wang, Q. (2021). Mog1 knockout causes cardiac hypertrophy and heart failure by downregulating tbx5‐cryab‐hspb2 signalling in zebrafish. Acta Physiologica, 231(3), e13567.

Wang, L., Wang, F., Liu, K., Long, C., Chen, Y., Li, C., ... & Zhang, H. (2021). αB‐crystallin/HSPB2 is critical for hyperactive mTOR‐induced cardiomyopathy. Journal of Cellular Physiology, 236(12), 8110-8121.

Yu, Z., Wang, H., Fang, Y., Lu, L., Li, M., Yan, B., ... & Teng, C. (2020). Molecular chaperone HspB2 inhibited pancreatic cancer cell proliferation via activating p53 downstream gene RPRM, BAI1, and TSAP6. Journal of cellular biochemistry, 121(3), 2318-2329.

Kim, N., Yu, L., Dawe, R., Petyuk, V. A., Gaiteri, C., De Jager, P. L., ... & Bennett, D. A. (2019). Microstructural changes in the brain mediate the association of AK4, IGFBP5, HSPB2, and ITPK1 with cognitive decline. Neurobiology of aging, 84, 17-25.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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