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Mouse Anti-ID2 Recombinant Antibody (CBYY-I1873) (CBMAB-I3043-YY)

This product is Mouse antibody that recognizes ID2. The antibody CBYY-I1873 can be used for immunoassay techniques such as: WB, IHC, IF
See all ID2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-I1873
Antibody Isotype
IgG2b
Application
WB, IHC, IF

Basic Information

Immunogen
Full length human recombinant protein of human ID2 (NP_002157)
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, PH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.99 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Inhibitor Of DNA Binding 2
Introduction
The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3.
Entrez Gene ID
3398
UniProt ID
Q02363
Alternative Names
Inhibitor Of DNA Binding 2
Function
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.
Biological Process
Bundle of His development Source: BHF-UCL
Cell differentiation Source: GO_Central
Cellular senescence Source: UniProtKB
Circadian regulation of gene expression Source: UniProtKB
Circadian rhythm Source: ARUK-UCL
Embryonic digestive tract morphogenesis Source: UniProtKB
Endodermal digestive tract morphogenesis Source: UniProtKB
Entrainment of circadian clock by photoperiod Source: UniProtKB
Enucleate erythrocyte differentiation Source: ARUK-UCL
Epithelial cell differentiation involved in mammary gland alveolus development Source: UniProtKB
Heart development Source: BHF-UCL
Locomotor rhythm Source: UniProtKB
Mammary gland alveolus development Source: UniProtKB
Mammary gland epithelial cell proliferation Source: UniProtKB
Negative regulation of B cell differentiation Source: ARUK-UCL
Negative regulation of DNA-binding transcription factor activity Source: GDB
Negative regulation of gene expression Source: UniProtKB
Negative regulation of muscle cell differentiation Source: ARUK-UCL
Negative regulation of transcription, DNA-templated Source: GDB
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Neuron fate commitment Source: UniProtKB
Olfactory bulb development Source: ARUK-UCL
Positive regulation of astrocyte differentiation Source: ARUK-UCL
Positive regulation of blood pressure Source: UniProtKB
Positive regulation of fat cell differentiation Source: ARUK-UCL
Positive regulation of gene expression Source: UniProtKB
Positive regulation of macrophage differentiation Source: ARUK-UCL
Positive regulation of smooth muscle cell proliferation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription involved in G1/S transition of mitotic cell cycle Source: BHF-UCL
Regulation of circadian rhythm Source: UniProtKB
Regulation of G1/S transition of mitotic cell cycle Source: BHF-UCL
Regulation of lipid metabolic process Source: UniProtKB
Regulation of neural precursor cell proliferation Source: UniProtKB
Regulation of neuron differentiation Source: UniProtKB
Cellular Location
Cytoplasm; Nucleus

Koppenhafer, S. L., Goss, K. L., Voigt, E., Croushore, E., Terry, W. W., Ostergaard, J., ... & Gordon, D. J. (2022). Inhibitor of DNA binding 2 (ID2) regulates the expression of developmental genes and tumorigenesis in ewing sarcoma. Oncogene, 41(20), 2873-2884.

Liu, F., Chen, S., Yu, Y., Huang, C., Chen, H., Wang, L., ... & Ye, Y. (2022). Inhibitor of DNA binding 2 knockdown inhibits the growth and liver metastasis of colorectal cancer. Gene, 819, 146240.

Yun, T., Ko, H. R., Jo, D. G., Park, K. W., Cho, S. W., Kim, J., & Ahn, J. Y. (2021). Inhibitor of DNA binding 2 (Id2) mediates microtubule polymerization in the brain by regulating αK40 acetylation of α-tubulin. Cell Death Discovery, 7(1), 257.

Kim, H. R., Moon, J. H., Lee, J. H., & Lim, Y. C. (2021). Inhibitor of DNA binding 2 (ID2): a novel marker for lymph node metastasis in head and neck squamous cell carcinoma. Annals of Surgical Oncology, 1-10.

Huang, Z. H., Feng, A. Y., Liu, J., Zhou, L., Zhou, B., & Yu, P. (2021). Inhibitor of DNA binding 2 accelerates nerve regeneration after sciatic nerve injury in mice. Neural Regeneration Research, 16(12), 2542.

Duffield, G. E., Han, S., Hou, T. Y., de la Iglesia, H. O., McDonald, K. A., Mecklenburg, K. L., & Robles-Murguia, M. (2020). Inhibitor of DNA binding 2 (Id2) Regulates Photic Entrainment Responses in Mice: Differential Responses of the Id2-/-Mouse Circadian System Are Dependent on Circadian Phase and on Duration and Intensity of Light. Journal of Biological Rhythms, 35(6), 555-575.

Zhou, Y., Huan, L., Wu, Y., Bao, C., Chen, B., Wang, L., ... & He, X. (2020). LncRNA ID2-AS1 suppresses tumor metastasis by activating the HDAC8/ID2 pathway in hepatocellular carcinoma. Cancer letters, 469, 399-409.

Huang, Z., Liu, J., Jin, J., Chen, Q., Shields, L. B., Zhang, Y. P., ... & Yu, P. (2019). Inhibitor of DNA binding 2 promotes axonal growth through upregulation of Neurogenin2. Experimental Neurology, 320, 112966.

Han, J., Seo, H., Choi, Y., Lee, C., Kim, M. I., Jeon, Y., ... & Ka, H. (2018). Expression and regulation of inhibitor of DNA binding proteins ID1, ID2, ID3, and ID4 at the maternal-conceptus interface in pigs. Theriogenology, 108, 46-55.

Wen, X. F., Chen, M., Wu, Y., Chen, M. N., Glogowska, A., Klonisch, T., & Zhang, G. J. (2018). Inhibitor of DNA binding 2 inhibits epithelial-mesenchymal transition via up-regulation of Notch3 in breast cancer. Translational Oncology, 11(5), 1259-1270.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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