Sign in or Register   Sign in or Register
  |  

Mouse Anti-ING2 Recombinant Antibody (1D1) (CBMAB-I0646-YY)

This product is Mouse antibody that recognizes ING2. The antibody 1D1 can be used for immunoassay techniques such as: ELISA, IF, WB
See all ING2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D1
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
inhibitor of growth family, member 2
Introduction
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
3622
UniProt ID
Q9H160
Alternative Names
Inhibitor Of Growth Family Member 2
Function
Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
Biological Process
Chromatin organizationIEA:UniProtKB-KW
Flagellated sperm motilityBy SimilarityISS:BHF-UCL
Male germ-line stem cell asymmetric divisionBy SimilarityISS:BHF-UCL
Male meiosis IBy SimilarityISS:BHF-UCL
Negative regulation of cell population proliferationIEA:InterPro
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of histone deacetylationBy SimilarityISS:BHF-UCL
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cellular senescence1 PublicationNAS:BHF-UCL
Regulation of growthIEA:UniProtKB-KW
Regulation of response to DNA damage stimulus1 PublicationNAS:BHF-UCL
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Seminiferous tubule developmentBy SimilarityISS:BHF-UCL
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Spermatid developmentBy SimilarityISS:BHF-UCL
SpermatogenesisBy SimilarityISS:BHF-UCL
Cellular Location
Nucleus. Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.
PTM
Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-ING2 Recombinant Antibody (1D1)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare