ING2

This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. [provided by RefSeq]

Full Name

inhibitor of growth family, member 2

Function

Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).

Biological Process

Chromatin organizationIEA:UniProtKB-KW
Flagellated sperm motilityBy SimilarityISS:BHF-UCL
Male germ-line stem cell asymmetric divisionBy SimilarityISS:BHF-UCL
Male meiosis IBy SimilarityISS:BHF-UCL
Negative regulation of cell population proliferationIEA:InterPro
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of histone deacetylationBy SimilarityISS:BHF-UCL
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cellular senescence1 PublicationNAS:BHF-UCL
Regulation of growthIEA:UniProtKB-KW
Regulation of response to DNA damage stimulus1 PublicationNAS:BHF-UCL
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Seminiferous tubule developmentBy SimilarityISS:BHF-UCL
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Spermatid developmentBy SimilarityISS:BHF-UCL
SpermatogenesisBy SimilarityISS:BHF-UCL

Cellular Location

Nucleus. Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.

PTM

Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71.