Sign in or Register   Sign in or Register
  |  

Mouse Anti-JAK1 Recombinant Antibody (1G1) (CBMAB-0099-WJ)

This product is a mouse antibody that recognizes JAK1. The antibody 1G1 can be used for immunoassay techniques such as: WB, IHC-P, IF, IP.
See all JAK1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
1G1
Antibody Isotype
IgG1
Application
WB, IHC-P, IF, IP

Basic Information

Immunogen
The internal region of mouse JAK1 (amino acids 785-815).
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Janus kinase 1
Introduction
JAK1 (Janus Kinase 1) is a Protein Coding gene for a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. Diseases associated with JAK1 include Hepatitis C and Polycythemia Vera. An important paralog of this gene is TYK2.
Entrez Gene ID
Human3716
Mouse16451
Rat84598
UniProt ID
HumanP23458
MouseP52332
RatG3V9W2
Alternative Names
JTK3; JAK1A; JAK1B
Function
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558, PubMed:28111307, PubMed:32750333, PubMed:16239216).
Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952).
Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:16239216, PubMed:32750333).
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Interferon-gamma-mediated signaling pathwayTAS:Reactome
Interleukin-2-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Interleukin-6-mediated signaling pathwayTAS:Reactome
Intracellular signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of homotypic cell-cell adhesionManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of sprouting angiogenesisManual Assertion Based On ExperimentIGI:BHF-UCL
Protein localization to cell-cell junctionManual Assertion Based On ExperimentIMP:ARUK-UCL
Protein phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIMP:UniProtKB
Response to antibioticManual Assertion Based On ExperimentIDA:MGI
Type I interferon signaling pathwayTAS:Reactome
Cellular Location
Endomembrane system. Wholly intracellular, possibly membrane associated.
Involvement in disease
Autoinflammation, immune dysregulation, and eosinophilia (AIIDE):
An autosomal dominant disorder characterized by immune dysregulation, severe atopic dermatitis, and chronic gastrointestinal inflammation. Additional features include asthma, food or environmental allergies, as well as poor overall growth with short stature.
PTM
Autophosphorylated (PubMed:7615558).
Phosphorylated on tyrosine residues in response to interferon gamma signaling (PubMed:7615558).
Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling (PubMed:11909529).
Ubiquitinated by RNF125; leading to its degradation by the proteasome.

Chapman, S., Kwa, M., Gold, L. S., & Lim, H. W. (2022). Janus kinase inhibitors in dermatology: Part I. A comprehensive review. Journal of the American Academy of Dermatology, 86(2), 406-413.

Roskoski Jr, R. (2022). Janus kinase (JAK) inhibitors in the treatment of neoplastic and inflammatory disorders. Pharmacological Research, 106362.

Spinelli, F. R., Colbert, R. A., & Gadina, M. (2021). JAK1: Number one in the family; number one in inflammation?. Rheumatology, 60(Supplement_2), ii3-ii10.

Fetter, T., Smith, P., Guel, T., Braegelmann, C., Bieber, T., & Wenzel, J. (2020). Selective janus kinase 1 inhibition is a promising therapeutic approach for lupus erythematosus skin lesions. Frontiers in Immunology, 11, 344.

Choy, E. H. (2019). Clinical significance of Janus Kinase inhibitor selectivity. Rheumatology, 58(6), 953-962.

Zak, M., Hanan, E. J., Lupardus, P., Brown, D. G., Robinson, C., Siu, M., ... & Johnson, A. (2019). Discovery of a class of highly potent Janus kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorganic & medicinal chemistry letters, 29(12), 1522-1531.

Papadopoulou, C., Hong, Y., Omoyinmi, E., Brogan, P. A., & Eleftheriou, D. (2019). Janus kinase 1/2 inhibition with baricitinib in the treatment of juvenile dermatomyositis. Brain, 142(3), e8-e8.

Abdou, A. G., Maraee, A., Yassien, H., & Sarhan, M. (2018). Immunohistochemistry of Janus kinase 1 (JAK1) expression in vitiligo. Journal of Pathology and Translational Medicine, 52(6), 363-368.

Jarocha, D. J., Gadue, P., Tong, W., Newton, R. C., & Poncz, M. (2018). Janus kinase (JAK) 1 inhibition affects both megakaryopoiesis and thrombopoiesis. Blood, 132, 2559.

Wehde, B. L., Rädler, P. D., Shrestha, H., Johnson, S. J., Triplett, A. A., & Wagner, K. U. (2018). Janus kinase 1 plays a critical role in mammary cancer progression. Cell reports, 25(8), 2192-2207.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Anti-JAK1 Recombinant Antibody (1G1)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare