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Mouse Anti-KAT8 Recombinant Antibody (A731) (CBMAB-AP4077LY)

The product is antibody recognizes KAT8. The antibody A731 immunoassay techniques such as: ELISA, ICC, IHC, WB.
See all KAT8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
A731
Antibody Isotype
IgG
Application
ELISA, ICC, IHC, WB

Basic Information

Immunogen
Purified recombinant fragment of human MYST1 expressed in E. Coli
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Lysine Acetyltransferase 8
Introduction
This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Entrez Gene ID
84148
UniProt ID
Q9H7Z6
Alternative Names
Lysine Acetyltransferase 8; MOZ, YBF2/SAS3, SAS2 And TIP60 Protein 1; MYST Histone Acetyltransferase 1; K(Lysine) Acetyltransferase 8; MYST-1; MYST1; HMOF; MOF;
Function
Histone acetyltransferase which may be involved in transcriptional activation (PubMed:12397079, PubMed:22020126).
May influence the function of ATM (PubMed:15923642).
As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac (PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22547026, PubMed:22020126).
As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852, PubMed:22547026).
That activity is less specific than the one of the MSL complex (PubMed:20018852, PubMed:22547026).
Can also acetylate TP53/p53 at 'Lys-120'.
Biological Process
Chromatin organizationIEA:UniProtKB-KW
Histone acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H4-K16 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H4-K5 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H4-K8 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Myeloid cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of histone H3-K4 methylationManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of autophagyManual Assertion Based On ExperimentIDA:MGI
Regulation of dosage compensation by inactivation of X chromosomeIEA:Ensembl
Cellular Location
Nucleus; Chromosome
Involvement in disease
Li-Ghorbani-Weisz-Hubshman syndrome (LIGOWS):
An autosomal dominant disorder characterized by global developmental delay, mild to moderate intellectual disability, speech and language impairment, and variable facial dysmorphism. Some patients have seizures and autistic features. Brain imaging abnormalities are observed in some patients and include decreased white matter volume, enlarged ventricles, thin corpus callosum, and gray matter nodular heterotopia.
PTM
Autoacetylation at Lys-274 is required for binding histone H4 with high affinity and for proper function.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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