Rabbit Anti-KAT8 Recombinant Antibody (CBLY1-004) (CBMAB-K0045-LY)

Name: Rabbit Anti-KAT8 Recombinant Antibody (CBLY1-004)
SKU: CBMAB-K0045-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBLY1-004

Application

ICC/IF

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Lysine Acetyltransferase 8

Introduction

This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Entrez Gene ID

84148

UniProt ID

Q9H7Z6

Alternative Names

Lysine Acetyltransferase 8; MOZ; YBF2/SAS3; SAS2 And TIP60 Protein 1; MYST Histone Acetyltransferase 1; K(Lysine) Acetyltransferase 8; MYST-1; MYST1; HMOF; MOF;

Function

Histone acetyltransferase which may be involved in transcriptional activation (PubMed:12397079, PubMed:22020126).
May influence the function of ATM (PubMed:15923642).
As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac (PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22547026, PubMed:22020126).
As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852, PubMed:22547026).
That activity is less specific than the one of the MSL complex (PubMed:20018852, PubMed:22547026).
Can also acetylate TP53/p53 at 'Lys-120'.

Biological Process

Chromatin organizationIEA:UniProtKB-KW
Histone acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H4-K16 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H4-K5 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H4-K8 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Myeloid cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of histone H3-K4 methylationManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of autophagyManual Assertion Based On ExperimentIDA:MGI
Regulation of dosage compensation by inactivation of X chromosomeIEA:Ensembl

Cellular Location

Nucleus; Chromosome

Involvement in disease

Li-Ghorbani-Weisz-Hubshman syndrome (LIGOWS):
An autosomal dominant disorder characterized by global developmental delay, mild to moderate intellectual disability, speech and language impairment, and variable facial dysmorphism. Some patients have seizures and autistic features. Brain imaging abnormalities are observed in some patients and include decreased white matter volume, enlarged ventricles, thin corpus callosum, and gray matter nodular heterotopia.

PTM

Autoacetylation at Lys-274 is required for binding histone H4 with high affinity and for proper function.

Fiorentino, F., Sementilli, S., Menna, M., Turrisi, F., Tomassi, S., Pellegrini, F. R., ... & Rotili, D. (2023). First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8. Journal of Medicinal Chemistry.

Radzisheuskaya, A., Shliaha, P. V., Grinev, V. V., Shlyueva, D., Damhofer, H., Koche, R., ... & Helin, K. (2021). Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis. Molecular Cell, 81(8), 1749-1765.

Burrell, J. A., & Stephens, J. M. (2021). KAT8, lysine acetyltransferase 8, is required for adipocyte differentiation in vitro. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1867(6), 166103.

Proietti, G., Wang, Y., Punzo, C., & Mecinović, J. (2021). Substrate scope for human histone lysine acetyltransferase KAT8. International Journal of Molecular Sciences, 22(2), 846.

Li, L., Ghorbani, M., Weisz-Hubshman, M., Rousseau, J., Thiffault, I., Schnur, R. E., ... & Yang, X. J. (2020). Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability. The Journal of clinical investigation, 130(3), 1431-1445.

Huai, W., Liu, X., Wang, C., Zhang, Y., Chen, X., Chen, X., ... & Cao, X. (2019). KAT8 selectively inhibits antiviral immunity by acetylating IRF3. Journal of Experimental Medicine, 216(4), 772-785.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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