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Mouse Anti-KAT8 Recombinant Antibody (CBT893) (V2LY-0625-LY3191)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT893
Antibody Isotype
IgG
Application
WB, IHC-P, IF, ICC, ELISA

Basic Information

Immunogen
Purified recombinant fragment of human MOF expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:10,000
IF1:200-1:1,000
IHC1:200-1:1,000
WB1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Buffer
BSA, Glycerol
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Lysine Acetyltransferase 8
Entrez Gene ID
84148
UniProt ID
Q9H7Z6
Function
Histone acetyltransferase which may be involved in transcriptional activation (PubMed:12397079, PubMed:22020126).
May influence the function of ATM (PubMed:15923642).
As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac (PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22547026, PubMed:22020126).
As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852, PubMed:22547026).
That activity is less specific than the one of the MSL complex (PubMed:20018852, PubMed:22547026).
Can also acetylate TP53/p53 at 'Lys-120'.
Biological Process
Chromatin organizationIEA:UniProtKB-KW
Histone acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H4-K16 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H4-K5 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H4-K8 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Myeloid cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of histone H3-K4 methylationManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of autophagyManual Assertion Based On ExperimentIDA:MGI
Regulation of dosage compensation by inactivation of X chromosomeIEA:Ensembl
Cellular Location
Nucleus; Chromosome
Involvement in disease
Li-Ghorbani-Weisz-Hubshman syndrome (LIGOWS):
An autosomal dominant disorder characterized by global developmental delay, mild to moderate intellectual disability, speech and language impairment, and variable facial dysmorphism. Some patients have seizures and autistic features. Brain imaging abnormalities are observed in some patients and include decreased white matter volume, enlarged ventricles, thin corpus callosum, and gray matter nodular heterotopia.
PTM
Autoacetylation at Lys-274 is required for binding histone H4 with high affinity and for proper function.
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For research use only. Not intended for any clinical use.

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