Mouse Anti-KDM5C Recombinant Antibody (CBLXK-015) (CBMAB-2220CQ)

Name: Mouse Anti-KDM5C Recombinant Antibody (CBLXK-015)
SKU: CBMAB-2220CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLXK-015

Application

WB, ICC

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Lysine Demethylase 5C

Introduction

This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked cognitive disability. Alternative splicing results in multiple transcript variants. Diseases associated with KDM5C include Mental Retardation, X-Linked, Syndromic, Claes-Jensen Type and Alacrima, Achalasia, And Mental Retardation Syndrome. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. An important paralog of this gene is KDM5D.

Entrez Gene ID

8242

UniProt ID

P41229

Alternative Names

KDM5C; lysine (K)-specific demethylase 5C; JARID1C, jumonji, AT rich interactive domain 1C, Jumonji, AT rich interactive domain 1C (RBP2 like), SMCX, Smcy homolog, X linked (mouse); lysine-specific demethylase 5C; DXS1272E; XE169; protein SmcX; selected cDNA on X; Smcy homolog, X-linked; Smcx homolog, X chromosome; histone demethylase JARID1C; JmjC domain-containing protein SMCX; Jumonji/ARID domain-containing protein 1C; Jumonji, AT rich interactive domain 1C (RBP2-like); MRXJ; SMCX; MRXSJ; MRXSCJ; JARID1C

Function

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558).
Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).

Biological Process

Chromatin remodelingManual Assertion Based On ExperimentIBA:GO_Central
Histone H3-K4 demethylationManual Assertion Based On ExperimentIDA:MGI
Negative regulation of transcription, DNA-templatedISS:UniProtKB
Response to toxic substanceIEA:Ensembl
Rhythmic processIEA:UniProtKB-KW

Cellular Location

Nucleus

Involvement in disease

Intellectual developmental disorder, X-linked, syndromic, Claes-Jensen type (MRXSCJ):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXSCJ patients manifest mental retardation associated with variable features such as slowly progressive spastic paraplegia, seizures, facial dysmorphism.

Leonardi, E., Aspromonte, M. C., Drongitis, D., Bettella, E., Verrillo, L., Polli, R., ... & Murgia, A. (2023). Expanding the genetics and phenotypic spectrum of Lysine-specific demethylase 5C (KDM5C): a report of 13 novel variants. European Journal of Human Genetics, 31(2), 202-215.

Samanta, M. K., Gayen, S., Harris, C., Maclary, E., Murata-Nakamura, Y., Malcore, R. M., ... & Kalantry, S. (2022). Activation of Xist by an evolutionarily conserved function of KDM5C demethylase. Nature Communications, 13(1), 2602.

Lemster, A. L., Sievers, E., Pasternack, H., Lazar-Karsten, P., Klümper, N., Sailer, V., ... & Kirfel, J. (2022). Histone demethylase KDM5C drives prostate cancer progression by promoting EMT. Cancers, 14(8), 1894.

Shen, H. F., Zhang, W. J., Huang, Y., He, Y. H., Hu, G. S., Wang, L., ... & Liu, W. (2021). The dual function of KDM5C in both gene transcriptional activation and repression promotes breast cancer cell growth and tumorigenesis. Advanced Science, 8(9), 2004635.

Lin, H., Ma, N., Zhao, L., Yang, G., & Cao, B. (2020). KDM5c promotes colon cancer cell proliferation through the FBXW7-c-Jun regulatory axis. Frontiers in Oncology, 10, 535449.

Carmignac, V., Nambot, S., Lehalle, D., Callier, P., Moortgat, S., Benoit, V., ... & Thauvin‐Robinet, C. (2020). Further delineation of the female phenotype with KDM5C disease causing variants: 19 new individuals and review of the literature. Clinical Genetics, 98(1), 43-55.

Link, J. C., Wiese, C. B., Chen, X., Avetisyan, R., Ronquillo, E., Ma, F., ... & Reue, K. (2020). X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity. The Journal of clinical investigation, 130(11), 5688-5702.

Hong, Z., Wu, G., Xiang, Z. D., Xu, C. D., Huang, S. S., Li, C., ... & Wu, D. L. (2019). KDM5C is transcriptionally regulated by BRD4 and promotes castration-resistance prostate cancer cell proliferation by repressing PTEN. Biomedicine & Pharmacotherapy, 114, 108793.

Chang, S., Yim, S., & Park, H. (2019). The cancer driver genes IDH1/2, JARID1C/KDM5C, and UTX/KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism. Experimental & molecular medicine, 51(6), 1-17.

Vallianatos, C. N., Farrehi, C., Friez, M. J., Burmeister, M., Keegan, C. E., & Iwase, S. (2018). Altered gene-regulatory function of KDM5C by a novel mutation associated with autism and intellectual disability. Frontiers in molecular neuroscience, 11, 104.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
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For research use only. Not intended for any clinical use.

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