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KDM5C

This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Full Name

Lysine Demethylase 5C

Function

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558).
Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).

Biological Process

Chromatin remodelingManual Assertion Based On ExperimentIBA:GO_Central
Histone H3-K4 demethylationManual Assertion Based On ExperimentIDA:MGI
Negative regulation of transcription, DNA-templatedISS:UniProtKB
Response to toxic substanceIEA:Ensembl
Rhythmic processIEA:UniProtKB-KW

Cellular Location

Nucleus

Involvement in disease

Intellectual developmental disorder, X-linked, syndromic, Claes-Jensen type (MRXSCJ):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXSCJ patients manifest mental retardation associated with variable features such as slowly progressive spastic paraplegia, seizures, facial dysmorphism.

Anti-KDM5C antibodies

Mouse Anti-KDM5C Recombinant Antibody (CBLXK-015) (CBMAB-2220CQ)

SDS

Target: KDM5C

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLXK-015

Application*: WB, IC

Mouse Anti-KDM5C Recombinant Antibody (CBLXK-014) (CBMAB-2219CQ)

SDS

Target: KDM5C

Host: Mouse

Antibody Isotype: IgG

Specificity: Cattle, Dog, Human, Mouse, Rat

Clone: CBLXK-014

Application*: IF, P, WB

Mouse Anti-KDM5C Recombinant Antibody (CBLXK-013) (CBMAB-2218CQ)

SDS

Target: KDM5C

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLXK-013

Application*: E, WB, IC

Rabbit Anti-KDM5C Recombinant Antibody (CBLXK-012) (CBMAB-2217CQ)

SDS

Target: KDM5C

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Monkey, Horse, Pig

Clone: CBLXK-012

Application*: WB, IP

Mouse Anti-KDM5C Recombinant Antibody (CBLXK-011) (CBMAB-2216CQ)

SDS

Target: KDM5C

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLXK-011

Application*: WB, IF

Mouse Anti-KDM5C Recombinant Antibody (CBLXK-010) (CBMAB-2215CQ)

SDS

Target: KDM5C

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat, Dog

Clone: CBLXK-010

Application*: WB, IC

Mouse Anti-KDM5C Recombinant Antibody (CBLXK-009) (CBMAB-2214CQ)

SDS

Target: KDM5C

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLXK-009

Application*: IP

Mouse Anti-KDM5C Antibody (1A11) (CBMAB-0576-YC)

SDS

Target: KDM5C

Host: Mouse

Antibody Isotype: IgG2c

Specificity: Human

Clone: 1A11

Application*: E, IP, WB

Mouse Anti-KDM5C Recombinant Antibody (EG1782) (CBMAB-EN2125-LY)

SDS

Target: KDM5C

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: EG1782

Application*: WB, ICC

Mouse Anti-KDM5C Recombinant Antibody (EG1710) (CBMAB-EN2048-LY)

SDS

Target: KDM5C

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: EG1710

Application*: ELISA, WB

Mouse Anti-KDM5C Recombinant Antibody (A750) (CBMAB-AP11122LY)

SDS

Target: KDM5C

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: A750

Application*: ICC, WB

Mouse Anti-KDM5C Recombinant Antibody (A749) (CBMAB-AP4074LY)

SDS

Target: KDM5C

Host: Mouse

Antibody Isotype: IgG

Specificity: Dog, Human, Mouse, Rat

Clone: A749

Application*: ELISA, ICC, WB

Mouse Anti-KDM5C Recombinant Antibody (CB413A) (CBMAB-CA413LY)

SDS

Target: KDM5C

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat, Dog

Clone: CB413A

Application*: ELISA, WB, ICC

Mouse Anti-KDM5C Recombinant Antibody (15B197) (CBMAB-K0707-LY)

SDS

Target: KDM5C

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 15B197

Application*: IC, WB

Mouse Anti-KDM5C Recombinant Antibody (13k78) (CBMAB-K0706-LY)

SDS

Target: KDM5C

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 13k78

Application*: IC, WB

Mouse Anti-KDM5C Recombinant Antibody (A720) (CBMAB-AP10934LY)

SDS

Target: KDM5C

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: A720

Application*: ICC, WB

Mouse Anti-KDM5C Recombinant Antibody (A719) (CBMAB-AP4054LY)

SDS

Target: KDM5C

Host: Mouse

Antibody Isotype: IgG

Specificity: Dog, Human, Mouse, Rat

Clone: A719

Application*: ICC, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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