Human Recombinant KDM5C protein, GST Tag (V2LY-0526-LY5146)

Name: Human Recombinant KDM5C protein, GST Tag
SKU: V2LY-0526-LY5146
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant KDM5C protein, GST Tag consist of Amino Acid: 1-671 and predicts a molecular mass of 118 kDa.

Molecule Mass

118 kDa

Sequence

Amino Acid: 1-671

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Lysine Demethylase 5C

Function

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558).
Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).

Biological Process

Chromatin remodelingManual Assertion Based On ExperimentIBA:GO_Central
Histone H3-K4 demethylationManual Assertion Based On ExperimentIDA:MGI
Negative regulation of transcription, DNA-templatedISS:UniProtKB
Response to toxic substanceIEA:Ensembl
Rhythmic processIEA:UniProtKB-KW

Cellular Location

Nucleus

Involvement in disease

Intellectual developmental disorder, X-linked, syndromic, Claes-Jensen type (MRXSCJ):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXSCJ patients manifest mental retardation associated with variable features such as slowly progressive spastic paraplegia, seizures, facial dysmorphism.

Leonardi, E., Aspromonte, M. C., Drongitis, D., Bettella, E., Verrillo, L., Polli, R., ... & Murgia, A. (2023). Expanding the genetics and phenotypic spectrum of Lysine-specific demethylase 5C (KDM5C): a report of 13 novel variants. European Journal of Human Genetics, 31(2), 202-215.

Samanta, M. K., Gayen, S., Harris, C., Maclary, E., Murata-Nakamura, Y., Malcore, R. M., ... & Kalantry, S. (2022). Activation of Xist by an evolutionarily conserved function of KDM5C demethylase. Nature Communications, 13(1), 2602.

Lemster, A. L., Sievers, E., Pasternack, H., Lazar-Karsten, P., Klümper, N., Sailer, V., ... & Kirfel, J. (2022). Histone demethylase KDM5C drives prostate cancer progression by promoting EMT. Cancers, 14(8), 1894.

Shen, H. F., Zhang, W. J., Huang, Y., He, Y. H., Hu, G. S., Wang, L., ... & Liu, W. (2021). The dual function of KDM5C in both gene transcriptional activation and repression promotes breast cancer cell growth and tumorigenesis. Advanced Science, 8(9), 2004635.

Lin, H., Ma, N., Zhao, L., Yang, G., & Cao, B. (2020). KDM5c promotes colon cancer cell proliferation through the FBXW7-c-Jun regulatory axis. Frontiers in Oncology, 10, 535449.

Carmignac, V., Nambot, S., Lehalle, D., Callier, P., Moortgat, S., Benoit, V., ... & Thauvin‐Robinet, C. (2020). Further delineation of the female phenotype with KDM5C disease causing variants: 19 new individuals and review of the literature. Clinical Genetics, 98(1), 43-55.

Link, J. C., Wiese, C. B., Chen, X., Avetisyan, R., Ronquillo, E., Ma, F., ... & Reue, K. (2020). X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity. The Journal of clinical investigation, 130(11), 5688-5702.

Hong, Z., Wu, G., Xiang, Z. D., Xu, C. D., Huang, S. S., Li, C., ... & Wu, D. L. (2019). KDM5C is transcriptionally regulated by BRD4 and promotes castration-resistance prostate cancer cell proliferation by repressing PTEN. Biomedicine & Pharmacotherapy, 114, 108793.

Chang, S., Yim, S., & Park, H. (2019). The cancer driver genes IDH1/2, JARID1C/KDM5C, and UTX/KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism. Experimental & molecular medicine, 51(6), 1-17.

Vallianatos, C. N., Farrehi, C., Friez, M. J., Burmeister, M., Keegan, C. E., & Iwase, S. (2018). Altered gene-regulatory function of KDM5C by a novel mutation associated with autism and intellectual disability. Frontiers in molecular neuroscience, 11, 104.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
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Isotype control

For research use only. Not intended for any clinical use.

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