Mouse Anti-MBIP Recombinant Antibody (CF280) (CBMAB-FT223LY)

Name: Mouse Anti-MBIP Recombinant Antibody (CF280)
SKU: CBMAB-FT223LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CF280

Application

ELISA, WB, IHC, IP

Immunogen

MAP3K12 binding inhibitory protein 1

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50% glycerol

Preservative

0.02% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

MAP3K12 Binding Inhibitory Protein 1

Introduction

MBIP (MAP3K12 Binding Inhibitory Protein 1) is a Protein Coding gene. Among its related pathways are Chromatin organization. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase inhibitor activity.

Entrez Gene ID

51562

UniProt ID

Q9NS73

Function

Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Biological Process

Histone H3 acetylation Source: BHF-UCL
Histone H3-K14 acetylation Source: ComplexPortal
Positive regulation of gene expression Source: GO_Central
Positive regulation of JNK cascade Source: GO_Central
Regulation of cell cycle Source: ComplexPortal
Regulation of cell division Source: ComplexPortal
Regulation of embryonic development Source: ComplexPortal
Regulation of histone deacetylation Source: ComplexPortal
Regulation of transcription, DNA-templated Source: ComplexPortal
Regulation of transcription by RNA polymerase II Source: ComplexPortal
Regulation of tubulin deacetylation Source: ComplexPortal

Cellular Location

Nucleus
Cytoplasm and Cytosol
Note: Shows a cytoplasmic localization when coexpressed with MAP3K12.

Ma, Y., Hua, Y., Yin, X. J., Jiao, Y., Xu, E., Yan, T., ... & Zhang, L. (2024). MBIP promotes ESCC metastasis by activating MAPK pathway. Cellular Signalling, 111040.

Yanchun, M., Yuyan, H., Ye, J., Enwei, X., Ting, Y., Jian, Y., & Ling, Z. (2023). MBIP promotes ESCC metastasis by activating MAPK pathway.

Ochieng, J. K., Kundu, S. T., Bajaj, R., Leticia Rodriguez, B., Fradette, J. J., & Gibbons, D. L. (2020). MBIP (MAP3K12 binding inhibitory protein) drives NSCLC metastasis by JNK-dependent activation of MMPs. Oncogene, 39(43), 6719-6732.

Shareefi, G., Turkistani, A. N., Alsayyah, A., Kussaibi, H., Had, M. A., & Alkharsah, K. R. (2020). Pathway-affecting single nucleotide polymorphisms (SNPs) in RPS6KA1 and MBIP genes are associated with breast cancer risk. Asian Pacific Journal of Cancer Prevention: APJCP, 21(7), 2163.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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