Rabbit Anti-MEX3C Recombinant Antibody (D5T2Z) (CBMAB-CP2284-LY)

The product is antibody recognizes MEX3C. The antibody D5T2Z immunoassay techniques such as: WB.
See all MEX3C antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat

Clone

D5T2Z

Antibody Isotype

IgG

Application

Basic Information

Immunogen

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala54 of human MEX3C protein.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Mex-3 RNA Binding Family Member C

Introduction

This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. [provided by RefSeq, Oct 2009]

Entrez Gene ID

Human	51320
Mouse	240396
Rat	307271

UniProt ID

Human	Q5U5Q3
Mouse	Q05A36
Rat	D4A2R5

Alternative Names

Mex-3 RNA Binding Family Member C; RING Finger And KH Domain-Containing Protein 2; RING-Type E3 Ubiquitin Transferase MEX3C; Ring Finger And KH Domain Containing 2; RING Finger Protein 194; RNF194; RKHD2; RNA-Binding E3 Ubiquitin-Protein Ligase MEX3C;

Function

E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.

Biological Process

Chondrocyte hypertrophy Source: Ensembl
Energy homeostasis Source: Ensembl
Regulation of fat cell differentiation Source: Ensembl

Cellular Location

Cytoplasm
Nucleus
Note: Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation.

Involvement in disease

Genetic variations in MEX3C may be associated with susceptibility to essential hypertension.

References

Wang, K., Zhang, H. N., & Du, Y. (2023). MEX3C induces cognitive impairment in mice through autophagy inhibition. Brain and Behavior, 13(11), e3245.

Guo, J., Zhao, J., Xu, Q., & Huang, D. (2023). MEX3C as a potential target for hepatocellular carcinoma drug and immunity: combined therapy with Lenvatinib. BMC cancer, 23(1), 967.

Xiao, Y., Li, Y., Shi, D., Wang, X., Dai, S., Yang, M., ... & Song, L. (2022). MEX3C-mediated decay of SOCS3 mRNA promotes JAK2/STAT3 signaling to facilitate metastasis in hepatocellular carcinoma. Cancer Research, 82(22), 4191-4205.

Huang, K., Liu, D., & Su, C. (2021). Circ_0007841 accelerates ovarian cancer development through facilitating MEX3C expression by restraining miR-151-3p activity. Aging (albany NY), 13(8), 12058.

Du, Y., Sun, D., & Li, Y. (2020). Mex3c mutation affects lactation through impairing milk ejection in female mice. Bioscience Reports, 40(12), BSR20201285.

Du, Y., Huo, Q., Li, T., Sun, D., Sun, T., & Lu, Z. (2020). Construction of a Mex3c gene-deficient mouse model to study C-FOS expression in hypothalamic nuclei and observe morphological differences in embryonic neural tube development. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 26, e927334-1.

Chao, H., Deng, L., Xu, F., Yu, Z., Xu, X., Huang, J., & Zeng, T. (2019). MEX3C regulates lipid metabolism to promote bladder tumorigenesis through JNK pathway. OncoTargets and therapy, 12, 3285.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Datasheet
SDS
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