MEX3C

This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. [provided by RefSeq, Oct 2009]

Full Name

Mex-3 RNA Binding Family Member C

Function

E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.

Biological Process

Chondrocyte hypertrophy Source: Ensembl
Energy homeostasis Source: Ensembl
Regulation of fat cell differentiation Source: Ensembl

Cellular Location

Cytoplasm
Nucleus
Note: Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation.

Involvement in disease

Genetic variations in MEX3C may be associated with susceptibility to essential hypertension.